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Solution Conformations By NMR of Novel Peptides Related to Cell Wall Peptidoglycan

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Book cover Spectroscopy of Biological Molecules: Modern Trends

Abstract

Peptidoglycans, the ubiquitous constituents of bacterial cell walls, exhibit versatile biological activities including immunomodulating properties. We have synthesized novel derivatives of peptidoglycan monomer (PGM) 1 (R1-L-Ala-D-iGln-m-Dap(R2)-D-Ala-D-Ala, R1 = GlcNAc-MurNAc, R2 = H) with attached adamant-2-yl (Ad) residues: Ad-CH2CO-PGM 2 (Ad-PGM, R1 = GlcNAc-MurNAc, R2 = Ad) and the corresponding Ad-CH2CO-pentapeptide 3 (Ad-PP, R1 = H, R2 = Ad). Attachement of a bulky adamantyl group may, in principle, introduce conformational restraints into the PGM molecule and the pentapeptide derived thereof. We have therefore investigated the conformational properties of 2 and 3, using 2D NMR spectroscopy and molecular modelling, for solutions in DMSO.

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References

  • Bystrov, V. (1976) Prog. NMR Spectrosc. 10, 41–81.

    Article  Google Scholar 

  • Dyson, H.J., Merutka, G., Waltho, J.P., Lerner, R.A. and Wright, P.E. (1992) J. Mol. Biol, 226, 795–817.

    Article  PubMed  CAS  Google Scholar 

  • Matter, H., Szilágyi, L., Forgo, P., Marinić, Ž. and Klaić, B. (1997) J. Am. Chem. Soc., in press.

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  • Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons, New York.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Organic Chemistry, L. Kossuth University, H-4010, Debrecen, Hungary

    L. Szilágyi

  2. Antibiotics Research Group of the Hungarian Academy of Science, H-4010, Debrecen, Hungary

    T. E. Gunda

  3. Institute of Immunology, Rockefellerova 2, Zagreb, Croatia

    Đ. Ljevaković, B. Vranešić, J. Tomašić & V. šporec

Authors
  1. L. Szilágyi
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  2. T. E. Gunda
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  3. Đ. Ljevaković
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  4. B. Vranešić
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  5. J. Tomašić
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  6. V. šporec
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Editor information

Editors and Affiliations

  1. Instituto de Estructura de la Materia (CSIC), Madrid, Spain

    P. Carmona

  2. Universidad Nacional de Educación a Distancia, Madrid, Spain

    R. Navarro  & A. Hernanz  & 

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© 1997 Springer Science+Business Media Dordrecht

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Szilágyi, L., Gunda, T.E., Ljevaković, Đ., Vranešić, B., Tomašić, J., šporec, V. (1997). Solution Conformations By NMR of Novel Peptides Related to Cell Wall Peptidoglycan. In: Carmona, P., Navarro, R., Hernanz, A. (eds) Spectroscopy of Biological Molecules: Modern Trends. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5622-6_15

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  • DOI: https://doi.org/10.1007/978-94-011-5622-6_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6369-2

  • Online ISBN: 978-94-011-5622-6

  • eBook Packages: Springer Book Archive

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