Abstract
At present, the use of postmenopausal hormone replacement therapy (HRT) in women with a history of breast cancer is controversial [1–10]. HRT has long been considered to be contraindicated in postmenopausal women with a history of this disease, since estrogen could exert a stimulating effect on dormant residual breast cancer cells somewhere in the body or on the epithelium of the contralateral breast. Recently, however, questions have been raised as to whether this is correct, in view of the impact HRT can have on quality of life in breast cancer survivors.
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References
DiSaia PJ. Hormone-replacement therapy in patients with breast cancer: A reappraisal. Cancer 1993;71:1490–1500.
Marchant DJ. Estrogen-replacement therapy after breast cancer: Risks versus benefits. Cancer 1993;71:2169–76.
Wile AG, Opfell RW, Margileth DA. Hormone replacement therapy in previously treated breast cancer patients. Am J Surg 1993;165:372–75.
DiSaia PJ, Odicino F, Grosen EA, et al. Hormone replacement therapy in breast cancer. The Lancet 1993;342:1232.
Lobo RA. Hormone replacement therapy. Oestrogen replacement after treatment for breast cancer? The Lancet 1993;341:1313–14.
McNeil C. ERT for breast cancer survivors: A hot debate runs on little data. JNCI 1995:87; 1047–50.
Isaacs CJ, Swain SM. Hormone replacement therapy in women with a history of breast carcinoma. Review. Hemat Oncol Clin North Am 1994;8:179–95.
Sands R, Boshoff C, Jones A, Studd J. Hormone replacement therapy after a diagnosis of breast cancer. Menopause 1995;2:73–80.
Kenemans P and Scheele F. Hormone replacement therapy in patients with a history of breast cancer: Risks and options. Eur Menopause J 1996;3(2):99–105.
Kenemans P, Scheele F, Burger CW. Hormone replacement therapy and breast cancer morbidity, mortality and recurrence. Eur J Obstet Gynec Reprod Biol 1997; 71:199–203.
Grady D, Rubin SM, Petitti DB, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med 1992; 117:1016–37.
Ciocca DR, Vargas Roig LM. Estrogen receptors in human nontarget tissues: Biological and clinical implications. Endocr Reviews 1995;16:35–62.
Toniolo PO, Levitz M, Zeleniuch-Jacquotte A, et al. A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J Natl Cancer Inst 1995;87:190–97.
Negri E, La Vecchia C, Bruzzi P, et al. Risk factors for breast cancer: Pooled results from three Italian case-control studies. Am J Epidemiol 1988;128:1207–15.
Early Breast Cancer Trialists’ Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomized trials involving 31.000 recurrences and 24.000 deaths among 75.000 women. The Lancet 1992;339:I–15, 71–85.
Early Breast Cancer Trialists’ Collaborative Group. Ovarian ablation in early breast cancer: Overview of the randomized trials. The Lancet 1996;348:1189–96.
Buchanan RB, Blarney RW, Durrant KR, et al. A randomized comparison of tamoxifen with surgical oophorectomy in premenopausal patients with advanced breast cancer. J Clin Oncol 1986;4:1326–30.
Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogens, normal breast proliferation and breast cancer risk. Endocrin Reviews 1993; 15:17–35.
Spicer DV, Pike MC. The prevention of breast cancer through reduced ovarian steroid exposure. Acta Oncol 1992;31:167–74.
Wren BG. Hormonal replacement therapy and breast cancer. Eur Menopause J 1995;2:13–19.
Wren BG, Eden JA. Do progestogens reduce the risk of breast cancer? A review of the evidence. Menopause 1996;3:4–12.
Cline JM, Soderqvist G, von Schoultz E, Skoog L, von Schoultz B. Effect of hormone replacement therapy on the mammary gland of surgically postmenopausal cynomolgus macaques. Am J Obstet Gynecol 1996;174:93–100.
Kenemans P, Stampfer M. Hormone replacement therapy and breast cancer (Guest Editorial). Eur J Obstet Gynec Reprod Biol 1996;67:1–4.
Steinberg KK, Thacker SB, Smith SJ, et al. A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. J Am Med Assoc 1991;265:1985–90.
Sillero-Arenas M, Delgado Rodriguez M, Ridigues-Canteras R, Bueno-Cavanillas A, Galvez-Vargas R. Menopausal hormone replacement therapy and breast cancer: A meta-analysis. Obstet Gynecol 1992;72:286–94.
Colditz GA, Egan KM, Stampfer MJ. Hormone replacement therapy and risk of breast cancer: Results from epidemiologic studies. Am J Obstet Gynecol 1993;168:1473–80.
Colditz GA, Hankinson SE, Hunter DJ, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. New Engl J Med 1995;332:1589–93. “Reply to letters to the editor.” N Engl J Med 1995;333:1357–58.
Bergkvist L, Adami H-O, Persson I, et al. Prognosis after breast cancer diagnosis in women exposed to estrogen and estrogen-progesteron replacement therapy. Am J Epidemiol 1989;130:221–228.
Stoll BA. Hormone replacement therapy in women treated for breast cancer. Eur J Cancer Clin Oncol 1989;25:1909–13.
Powles TJ, Hickish T, Casey S, et al. Hormone replacement after breast cancer. The Lancet 1993;342:60–61.
Eden JA, Bush T, Nand S, Wren BG. A case-control study of combined continuous estrogen-progestin replacement therapy among women with a personal history of breast cancer. Menopause 1995;2:67–72.
DiSaia PJ, Grosen EA, Kurosaki T, Gildea M, Cowan B, Anton-Culver H. Hormone replacement therapy in breast cancer survivors: A cohort study. Am J Obstet Gynecol 1996;174:1494–98.
Vassilopoulou-Sellin R, Theriault RL. Randomized prospective trial of estrogen replacement therapy in women with a history of breast cancer. Monogr Natl Cancer Inst 1994; 16:153–59.
Kenemans P, Barentsen R, van de Weijer P. Alternative treatment in the presence of contraindications. In: Kenemans P, Barentsen R, van de Weijer P, editors. Practical HRT. Bussum, The Netherlands: Medicon Europe B.V., 1995: 157–58.
Kenemans P and von Mensdorff S. Current status of Tamoxifen treatment and cancer risk. CME J Gynec Oncol 1997;1:9–14.
Yang NN, Venugopalan M, Hardikar S, Glasebrook A. Identification of an estrogen response element activated by metabolites of 17-beta estradiol and raloxifene. Science 1996;73:1222–25.
Kloosterboer HJ, Schoonen WGEJ, Deckers GH, Klijn JGM. Effects of progestagens and Org OD14 in in vitro and in vivo tumor models. J Steroid Biochem Molec Biol 1994;49:311–18.
Loprinzi CL, Michalak JC, Quella SK, et al. Megestrol acetate for the prevention of hot flushes. N Engl J Med, 1994;331:347–52.
McDonald CC, Alexander FE, Thyte BW, Forrest AP, Stewart HJ. Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomized trial. Br MedJ 1995;311:977–80.
Kenemans P. Tamoxifen: Alternative hormone replacement therapy with an anti-oestrogen? Eur Menopause J 1996;3(1):3–5.
Leeuwen F van, Benraadt J, Coebergh JWW, et al. Risk of endometrial cancer after tamoxifen treatment of breast cancer. The Lancet 1994;343:448–52.
Rutqvist LE, Johansson H, Signomklao T, Johansson U, Fornander T, Wilking N. Adjuvant tamoxifen therapy for early stage breast cancer and second primary malignancies. J Natl Cancer Inst 1995;87:645–51.
Horn-Ross PL. Multiple primary cancers involving the breast. Epidemiol Rev 1993; 15:169–76.
Adami H, Bergström R, Hansen J. Age at first primary as a determinant of the incidence of bilateral breast cancer. Cancer 1985;55:643–47.
Kenemans P. Risk profile-based long-term hormone replacement therapy. Eur Menopause J 1995;2(4):3–4.
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Kenemans, P., Scheele, F. (1997). Hormone Replacement Therapy after Breast Cancer. In: Paoletti, R., Crosignani, P.G., Kenemans, P., Samsioe, G., Soma, M.R., Jackson, A.S. (eds) Women’s Health and Menopause. Medical Science Symposia Series, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5560-1_34
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DOI: https://doi.org/10.1007/978-94-011-5560-1_34
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