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Blood Flows in Cerebral Arteries After Suspension of Postmenopausal Hormone Replacement Therapy. A Randomized Crossover Study

  • Mauro Penotti
  • Laura Sironi
  • Elisabetta Castiglioni
  • Luigi Miglierina
  • Stefano De Marinis
  • Massimiliano Farina
  • Livio Gabrielli
  • Mario Vignali
Part of the Medical Science Symposia Series book series (MSSS, volume 11)

Abstract

To investigate the effects of the suspension of hormone replacement therapy (HRT) on cerebral blood flow, we evaluated 23 postmenopausal women who were on continuous administration of transdermal estradiol and cyclical supplementation of medroxyprogesterone acetate (MPA) for 12 days every second month. The duration of the study was 12 months.

Keywords

Postmenopausal Woman Hormone Replacement Therapy Pulsatility Index Middle Cerebral Artery Cyclical Supplementation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Walsh BW, Shiff I, Rosner B, Greenberg L, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement on the concentration and metabolism of plasma lipoproteins. N Engl J Med 1991;325:1196–1204.PubMedCrossRefGoogle Scholar
  2. 2.
    Sacks FM, McPherson R, Walsh BW. Effect of postmenopausal estrogen replacement on plasma Lp(a) lipoprotein concentrations. Arch Intern Med 1994;154:1106–10.PubMedCrossRefGoogle Scholar
  3. 3.
    Wagner JD, Clarkson TB, St. Clair RW, Schwenke DC, Adams MR. Estrogen replacement therapy (ERT) and coronary artery (CA) atherogenesis in surgically postmenopausal cynomolgus monkeys. Circulation 1989;80(Suppl II):A331.Google Scholar
  4. 4.
    Keany JF, Shwaery GT, Xu A, et al. 17 beta-estradiol preserves endothelial vasodilatator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation 1994;89:2251–59.CrossRefGoogle Scholar
  5. 5.
    Garg UC, Hassid A. Nitric oxide generating vasodilators and 9-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774–77.PubMedCrossRefGoogle Scholar
  6. 6.
    Radomski MW, Palmer RM, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987;2:1057–58.PubMedCrossRefGoogle Scholar
  7. 7.
    Reis SE, Gloth ST, Blumenthal RS, et al. Ethinil estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 1994;89:52–60.PubMedCrossRefGoogle Scholar
  8. 8.
    Pines A, Fisman EZ, Levo Y, et al. The effects of hormone replacement therapy in normal postmenopausal women: Measurements of doppler-derived parameters of aortic flow. Am J Obstet Gynecol 1991;164:806–12.PubMedGoogle Scholar
  9. 9.
    Gangar KF, Vyas S, Whitehead M, Crook D, Meire H, Campbell S. Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause. Lancet 1991;338:839–42.PubMedCrossRefGoogle Scholar
  10. 10.
    Penotti M, Nencioni T, Gabrielli L, Farina M, Castiglioni E, Polvani F. Blood flow variations in internal carotid and middle cerebral arteries induced by postmenopausal hormone replacement therapy. Am J Obstet Gynecol 1993;169:1226–32.PubMedGoogle Scholar
  11. 11.
    Stampfer MJ, Colditz GA, Willet WC, et al. Postmenopausal estrogen therapy and cardiovascular disease. N Engl J Med 1991;325:756–62.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • Mauro Penotti
  • Laura Sironi
  • Elisabetta Castiglioni
  • Luigi Miglierina
  • Stefano De Marinis
  • Massimiliano Farina
  • Livio Gabrielli
  • Mario Vignali

There are no affiliations available

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