Abstract
Bone marrow transplantation (BMT) from unrelated donors is being used increasingly for the treatment of leukemia and other haematopoietic disorders [1]. However, use of HLA phenotypically identical unrelated donors rather than genotypically identical siblings is associated with an increased incidence and severity of graft-versus-host disease (GvHD) [2-4]. This may be due to the presence of HLA disparities not identified because of the limited resolution of current HLA matching techniques [5]. Selection of histocompatible unrelated donors currently relies on tissue typing by serological and biochemical methods at HLA-A and HLA-B and molecular techniques at the DRB1 and DQB1 loci.
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References
Gratwohl, A. and Hermans, J. (1992) Bone marrow transplantation activity in Europe 1992, Bone Marrow Transplantation 13, 5–8.
Beatty, P.G., Hansen, J.A., Longton, G.M. et al. (1991) Marrow transplantation from HLA-matxhed unrelated donors for treatment oh hematologic malignancies, Transplantation 51, 443–447.
Anasetti, C., Beatty, P.G., Storb, R. et al. (1990) Effect of HLA Incompatibility on Graft-versus-Host Disease, Relapse and Survival after Marrow Transplantation for Patients with Leukemia or Lymphoma, Human Immunology 29, 79–91.
Hows, J., Bradley, B.A., Gore, S., Downie, T., Howard, M. and Gluckman, E. (1993) Prospective evaluation of unrelated donor marrow transplantation. The International Marrow Unrelated Search and Transplant, Bone Marrow Transplantation 12, 371–380.
Fleishhauer, K., Kerman, N., Reilly, R. et al. (1990) Bone Marrow - Allograft Rejection by T Lymphocytes Recognizing a Single Amino Acid Difference in HLA-B44, The New England Journal of Medicine 323, 1818–1822.
Weisdorf, D., Haake, R. and Blazar, B., Miller, W., McGlave, P.B., Ramsay, N., Kersey, J. and Filipovich, A.H. (1991) Risk factors for acute graft-versus-host disease in histocompatible donor bone marrow transplantation, Transplantation 51, 1197
Ochs, L.A., Miller, W.J., Filipovich, A.H., Haake, R.J., McGlave, P.B., Blaarb B.R., Ramsay, N.K., Kersey, J.H. and Weisdorf, D.J. (1994) Predictive factors for chronic graft-versus-host disease after histocompatible sibling donor bone marrow transplantation, Bone Marrow Transplantation 13, 455–460.
Smyth, L.A., Witt, C.S., Christiansen, F.T., Herrmann, R.P., Hollingsworth, P.N., Townend, D.C., Edward, E. and Dawkins, R.L. (1993) The MHC influences acute graft versus host disease in MHC matched adults undergoing allogeneic bone marrow transplantation, Bone Marrow Transplantation 12, 351–355.
Bacigalupo, A., Gualandi, F., Van Lint, M.T., Sessarego, M., Frassoni, F., Occhini, D., Lamparelli, T., Oneto, R., Vitale, V., Corvo, R. et al. (1993) Multivariate analysis of risk fectors for survival and relapse in chronic granulocytic leukemia following allogeneic marrow transplantation: impact of disease related variables (Sokal score), Bone Marrow Transplantation 12, 443–448.
Krausa, P., Brywka M., Savage, D., Hui, K.M. et al. (1995) Genetic polymorphism within HLA-A*02: Significant allelic variation revealed in different populations, Tissue Antigens 45, 223–231.
Krausa, P., Bodmer, J.G. and Browning, M.J. (1993) Defining the common subtypes of HLA A9, A10, A28 and A19 my use of ARMS/PCR, Tissue Antigens 42, 91–99.
Allen, M., Liu, L. and Gyllensten, U. (1994) A compresive polymerase chain reaction-oligonucleotide typing system for HLA class IA locus, Human Immunology 40, 25–32.
Gao, X., Jakobsen, I.B. and Serieantson, S.W. (1994) Characterization of the HLAA polymorphism by locus-specific polymerase chain reaction amplification and oligonucleotide hybridization, Human Immunology 41, 267–279.
Clay, T.M.C., Bidwell, J.L. Howard, M.R. and Bradley, B.A. (1991) PCRfingerprinting for selection of HLA matched unrelated marrow donors, Lancet 337, 1049–1052.
Tong, J.Y., Hammad, A., Rudert, W.A., Trucco, M. and Hsia, S. (1994) Heteroduplexes for HLA DQB1 identity of family members and kidney donor-recipient pairs, Transplantation 57, 741–745.
Sorrentino, R., Cascino, I. and Tosi, R. (1992) Subgrouping of DR4 alleles by DNA heteroduplex analysis, Human Immunology 33, 18–23.
Hoshino, S., Kimura, A., Fukuda, Y., Dohi, K. and Sasazuki, T. (1992) Polymerase chain reaction-single-strand conformation polymorphism analysis of polymorphism in DPA1 and DPB1 genes: A simple, economical, and rapid method for histocompatibility testing, Human Immunology 33, 98–107.
Blasczyk, R., Hahn, U., Wehling, J., Huhn, D. and Salama, A. (1995) Complete subtyping of the HLA-A locus by sequence-specific amplification folowed by direct sequencing or single-strand conformation polymorphism analysis, Tissue Antigens 46,86–95.
Petersdorf, E.W. and Hansen, J.A. (1995) A comprehensive approach for typing the alleles of the HLA-B locus by automated sequencing, Tissue Antigens 46, 73–85.
Arnett, K.L. and Parham, P. (1995) HLA Class I nucleotide sequences, Tissue Antigens 46, 217–257.
Garaghty, D.E., Koller, B.H., Hansen, J.A. and Orr, H.T. (1992) The HLA Class I gene family includes at least six genes and twelve pseudogenes and gene fragments, Journal of Immunology 149, 1934.
Parham, P., Adams, E. and Arnett, K.L. (1995) The origins of HLA-A,B,C polymorphism (Review), Immunological Reviews 143, 141–180.
Arguello, R., Avakian, O., Goldman, J. and Madrigal J.A. (In Press) PNAS.
Kaminski E., Hows, J., Bridge, J., Davey, N.J., Brookes, P.A., Green, J.E., Goldman, J.M. and Batchelor, J.R. (1991) Cytotoxic T lymphocite precursor (CTL-p) frequency analysis in unrelated donor bone marrow transplantation: two case studies, Bone Marrow Transplantation 8, 47–50.
Sharrok, C., Kaminski, S. and Man, S. (1990) Limiting dilution analysis of human T cells: A useful clinical tool, Immunology Today 11, 281–285.
Kaminski, E., Hows, J., Man, S., Brookes, P., Mackinnon, S., Hughes, T. Avakian, O. Goldman, J.M. and Batchelor, J.R. (1989) Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation, Transplantation 48, 608–613.
Roosnek, E., Hogendijk, S., Zawadynski, S., Speiser, D., Tiercy, J.M., Helg, C., Chapuis, B., Gratwohl, A., Gmur, J., Seger, R. et al. The frequency of pretransplant donor cytotoxic T cell precursors with anti-host specificity predicts survival of patients transplanted with bone marrow from donors other than HLA-identical siblings. Transplantation 56,691–696.
Fussell, S., Donnellan, M., Cooley, M. and Farrell, C. (1994) Cytotoxic T lymphocyte precursor frequency does not correlate with either the incidence or severity of graftversus-host disease after matched unrelated donor bone marrow transplantation, Transplantation 57, 673–676.
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© 1997 Springer Science+Business Media Dordrecht
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Madrigal, J.A. (1997). HLA Typing at the Molecular Level in the Process of Donor Selection for Bone Marrow Transplantation. In: Madrigal, A.J., Bencová, M., Middleton, D., Charron, D., Nánási, T. (eds) Immunogenetics: Advances and Education. NATO ASI Series, vol 35. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5486-4_15
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DOI: https://doi.org/10.1007/978-94-011-5486-4_15
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