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Biomolecular Structure and Dynamics

Part of the book series: NATO ASI Series ((NSSE,volume 342))

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Abstract

Knowledge of the three-dimensional structure is a prerequisite for the rational design of site-directed mutations in a protein and can be of great importance for the design of drugs. Structural information often greatly enhances our understanding of how proteins function and how they interact with each other or it can, for example, explain antigenic behaviour, DNA binding specificity, etc. X-ray crystallography and NMR spectroscopy are the only ways to obtain detailed structural information. Unfortunately, these techniques involve elaborate technical procedures and many proteins fail to crystallize at all and/or cannot be obtained or dissolved in large enough quantities for NMR measurements. The size of the protein is also a limiting factor for NMR.

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Authors and Affiliations

  1. Center for Genetic Engineering & Biotechnology, Havana, Cuba

    Rolando Rodriguez

  2. EMBL, 69117, Heidelberg, Germany

    Gerrit Vriend

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  1. Rolando Rodriguez
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  2. Gerrit Vriend
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Editors and Affiliations

  1. CRESIMM, Lille, Villeneuve d’Ascq, France

    Gérard Vergoten

  2. Department of Chemistry, University of Science and Technology, Lille, Villeneuve d’Ascq, France

    Gérard Vergoten

  3. Chemical Engineering Department, National Technical University of Athens, Zografou, Athens, Greece

    Theophile Theophanides

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Rodriguez, R., Vriend, G. (1997). Professional Gambling. In: Vergoten, G., Theophanides, T. (eds) Biomolecular Structure and Dynamics. NATO ASI Series, vol 342. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5484-0_5

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  • DOI: https://doi.org/10.1007/978-94-011-5484-0_5

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