Skip to main content

Correction of acid-base derangements

  • Chapter
Book cover Critical Care Nephrology

Abstract

Acid-base disorders, unless severe, usually pose little risk for patients and do not require urgent intervention. In mild cases, the physician should be less concerned about therapy than about why the disorder is present, since even minor acid-base disturbances can provide clues to the presence of serious underlying disease. On the other hand, when severe, an abnormal blood pH may itself threaten vital bodily functions and therefore demands prompt therapy aimed at correcting the acid-base imbalance. This chapter will discuss the management of these more severe disturbances. As will become apparent, the data used to support treatment recommendations are incomplete. Therefore, our recommendations in many cases will be based on clinical experience, rather than on clear evidence of improved outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Orringer CE, Eustace JC, Wunsch CD, Gardner LB. Natural history of lactic acidosis after grand-mal seizures: a model for the study of an anion-gap acidosis not associated with hyperkalemia. N Engl J Med 1977; 297: 796–9.

    Article  PubMed  CAS  Google Scholar 

  2. Madias NE. Lactic acidosis. Kidney Int 1986; 29: 752–74.

    Article  PubMed  CAS  Google Scholar 

  3. Mizock BA, Falk JL. Lactic acidosis in critical illness. Crit Care Med 1992; 20: 80–93.

    Article  PubMed  CAS  Google Scholar 

  4. Stacpoole PW, Wright EC, Baumgartner TG, et al. Natural history and course of acquired lactic acidosis in adults. Am J Med 1994; 97: 47–54.

    Article  PubMed  CAS  Google Scholar 

  5. Halperin ML, Cheema-Dhadli S, Halperin FA, Kamel KS. Rationale for the use of sodium bicarbonate in a patient with lactic acidosis due to a poor cardiac output. Nephron 1994; 66: 258–61.

    Article  PubMed  CAS  Google Scholar 

  6. Hindman BJ. Sodium bicarbonate in the treatment of subtypes of acute lactic acidosis: physiologic considerations. Anesthesiology 1990; 72: 1064–76.

    Article  PubMed  CAS  Google Scholar 

  7. Narins RG, Cohen JJ. Bicarbonate therapy for organic acidosis: the case for its continued use. Ann Intern Med 1987; 106: 615–8.

    PubMed  CAS  Google Scholar 

  8. Adrogue HJ, Tannen RL. Ketoacidosis, hyperosmolar states, and lactic acidosis. In: Kokko JP, Tannen RL (eds). Fluids and electrolytes. Philadelphia: W.B. Saunders, 1996: 643–74.

    Google Scholar 

  9. Ostrea EM, Odell GB. The influence of bicarbonate administration on blood pH in a “closed system”: clinical implications. J Pediatrics 1972; 80: 671–80.

    Article  CAS  Google Scholar 

  10. Bushinsky DA, Coe FL, Katzenberg C, Szidon JP, Parks JH. Arterial Pco2 in chronic metabolic acidosis. Kidney Int 1982; 22: 311–4.

    Article  PubMed  CAS  Google Scholar 

  11. Arieff AI. Indications for use of bicarbonate in patients with metabolic acidosis. Br J Anaesthesia 1991; 67: 165–77.

    Article  CAS  Google Scholar 

  12. Ayus JC, Krothapalli RK. Effect of bicarbonate administration on cardiac function. Am J Med 1989; 87: 5–6.

    Article  PubMed  CAS  Google Scholar 

  13. Cooper DJ, Worthley LIG. Adverse haemodynamic effects of sodium bicarbonate in metabolic acidosis. Intensive Care Med 1987; 13: 425–7.

    Article  PubMed  CAS  Google Scholar 

  14. Delany S, Stokes J. Bicarbonate administration in acidaemia -is it therapeutic? N Z Med J 1992; 105: 6–7.

    PubMed  CAS  Google Scholar 

  15. Gabow PA. Sodium bicarbonate: a cure or curse for metabolic acidosis? J Crit Illness 1989; 4: 13–28.

    Google Scholar 

  16. Gambassi G, Carbonin P. Bicarbonate is of no value. BMJ 1993; 307: 627.

    Article  PubMed  CAS  Google Scholar 

  17. Graf H, Arieff AI. The use of sodium bicarbonate in the therapy of organic acidosis. Intensive Care Med 1986; 12: 285–8.

    Article  PubMed  CAS  Google Scholar 

  18. Stacpoole PW. Lactic acidosis: the case against bicarbonate therapy. Ann Intern Med 1986; 105: 276–8.

    PubMed  CAS  Google Scholar 

  19. Young GP. Reservations and recommendations regarding sodium bicarbonate administration in cardiac arrest. J Emerg Med 1988; 6: 321–3.

    Article  PubMed  CAS  Google Scholar 

  20. Weisfeldt ML, Guerci AD. Sodium bicarbonate in CPR. JAMA 1991; 266: 2129–30.

    Article  PubMed  CAS  Google Scholar 

  21. Graf H, Leach W, Arieff AI. Evidence for a detrimental effect of bicarbonate therapy in hypoxic lactic acidosis. Science 1985; 227: 754–6.

    Article  PubMed  CAS  Google Scholar 

  22. Bishop RL, Weisfeldt ML. Sodium bicarbonate administration during cardiac arrest: effect on arterial pH, pCO2 and osmolality. JAMA 1976; 235: 506–9.

    Article  PubMed  CAS  Google Scholar 

  23. Ritter JM, Doktor HS, Benjamin N. Paradoxical effect of bicarbonate on cytoplasmic pH. Lancet 1990; 335: 1243–6.

    Article  PubMed  CAS  Google Scholar 

  24. Bersin RM, Arieff AI. Improved hemodynamic function during hypoxia with carbicarb, a new agent for the management of acidosis. Circulation 1988; 77: 227–33.

    Article  PubMed  CAS  Google Scholar 

  25. Kette F, Weil MH, von Planta M, Gazmuri RJ, Rackow EC. Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation. Circulation 1990; 81: 1660–6.

    Article  PubMed  CAS  Google Scholar 

  26. Kette F, Weil MH, Gazmuri RJ. Buffer solutions may compromise cardiac resuscitation by reducing coronary perfusion pressure. JAMA 1991; 266: 2121–6.

    Article  PubMed  CAS  Google Scholar 

  27. Rhee KH, Toro LO, McDonald GG, Nunnally RL, Levin DL. Carbicarb, sodium bicarbonate, and sodium chloride in hypoxic lactic acidosis. Chest 1993; 104: 913–8.

    Article  PubMed  CAS  Google Scholar 

  28. Levraut J, Labib Y, Chave S, Payan P, Raucoules-Aime M, Grimaud D. Effect of sodium bicarbonate on intracellular pH under different buffering conditions. Kidney Int 1996; 49: 1262–7.

    Article  PubMed  CAS  Google Scholar 

  29. Mattar JA, Weil MH, Shubin H, Stein L. Cardiac arrest in the critically ill. II. Hyperosmolal states following cardiac arrest. Am J Med 1974; 56: 162–8.

    Article  PubMed  CAS  Google Scholar 

  30. Cooper DJ, Walley KR, Wiggs BR, Russell JA. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis: a prospective, controlled clinical study. Ann Intern Med 1990; 112: 492–8.

    PubMed  CAS  Google Scholar 

  31. Mathieu D, Neviere R, Billard V, Fleyfel M, Wattel F. Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: a prospective, controlled clinical study. Crit Care Med 1991; 19: 1352–6.

    Article  PubMed  CAS  Google Scholar 

  32. Bersin RM, Chatterjee K, Arieff AI. Metabolic and hemodynamic consequences of sodium bicarbonate administration in patients with heart disease. Am J Med 1989; 87: 7–14.

    Article  PubMed  CAS  Google Scholar 

  33. Kaehny WD. Anderson RJ. Bicarbonate therapy of metabolic acidosis. Crit Care Med 1994; 22: 1525–7.

    PubMed  CAS  Google Scholar 

  34. Garella S, Dana CL, Chazan JA. Severity of metabolic acidosis as a determinant of bicarbonate requirements. N Engl J Med 1973; 289: 121–6.

    Article  PubMed  CAS  Google Scholar 

  35. Huseby JS, Gumprecht DG. Hemodynamic effects of rapid bolus hypertonic sodium bicarbonate. Chest 1981; 79: 552–4.

    Article  PubMed  CAS  Google Scholar 

  36. Adrogue HJ, Rashad MN, Gorin AB, Yacoub J, Madias NE. Assessing acid-base status in circulatory failure: differences between arterial and central venous blood. N Engl J Med 1989; 320: 1312–6.

    Article  PubMed  CAS  Google Scholar 

  37. Weil MH, Rackow EC, Trevino R, Grundler W, Falk JL, Griffel MI. Difference in acid-base state between venous and arterial blood during cardiopulmonary resuscitation. N Engl J Med 1986; 315: 153–6.

    Article  PubMed  CAS  Google Scholar 

  38. Emergency Cardiac Care Committee and Subcommittees, American Heart Association. Guidelines for cardiopulmonary resuscitation and emergency cardiac care, III: adult advanced cardiac life support. JAMA 1992; 268: 2199–241.

    Article  Google Scholar 

  39. von Planta M, Bar-Joseph G, Wiklund L, Bircher NG, Falk JL, Abramson NS. Pathophysiologic and therapeutic implications of acid-base changes during CPR. Ann Emerg Med 1993: 22: 404–10.

    Article  Google Scholar 

  40. Vukmir RB, Bircher NG, Radovsky A, Safar P. Sodium bicarbonate may improve outcome in dogs with brief or prolonged cardiac arrest. Crit Care Med 1995; 23: 515–22.

    Article  PubMed  CAS  Google Scholar 

  41. Filley GF, Kindig NB. Carbicarb, an alkalinizing ion-generating agent of possible clinical usefulness. Trans Am Clin Climatol Assoc 1984; 96: 141–53.

    Google Scholar 

  42. Shapiro JI, Elkins N, Logan J, Ferstenberg LB, Repine JE. Effects of sodium bicarbonate, disodium carbonate, and a sodium bicarbonate/carbonate mixture on the Pcoz of blood in a closed system. J Lab Clin Med 1995; 126: 65–9.

    PubMed  CAS  Google Scholar 

  43. Blecic S, De Backer D, Deleuze M, Vachiery JL, Vincent JL. Correction of metabolic acidosis in experimental CPR: a comparative study of sodium bicarbonate, carbicarb, and dextrose. Ann Emerg Med 1991; 20: 235–8.

    Article  PubMed  CAS  Google Scholar 

  44. Leung JM, Landow L, Franks M, et al. Safety and efficacy of intravenous carbicarb in patients undergoing surgery: comparison with sodium bicarbonate in the treatment of mild metabolic acidosis. Crit Care Med 1994; 22: 1540–9.

    PubMed  CAS  Google Scholar 

  45. Bleich HL, Schwartz WB. Tris buffer (THAM): an appraisal of its physiologic effects and clinical usefulness. N Engl J Med 1966; 274: 782–7

    Article  PubMed  CAS  Google Scholar 

  46. von Planta M, Gudipati C, Weil MH, Kraus LJ, Rackow EC. Effects of tromethamine and sodium bicarbonate buffers during cardiac resuscitation. J Clin Pharmacol 1988; 28: 594–9.

    Google Scholar 

  47. Stacpoole PW, Lorenz AC, Thomas RG, Harman EM. Dichloroacetate in the treatment of lactic acidosis. Ann Intern Med 1988; 108: 58–63.

    PubMed  CAS  Google Scholar 

  48. Stacpoole PW, Wright EC, Baumgartner TG, et al. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. N Engl J Med 1992; 327: 1564–9.

    Article  PubMed  CAS  Google Scholar 

  49. Lebovitz HE. Diabetic ketoacidosis. Lancet 1995; 345: 767–72.

    Article  PubMed  CAS  Google Scholar 

  50. Adrogue HJ, Eknoyan G, Suki WK. Diabetic ketoacidosis: role of the kidney in the acid-base homeostasis re-evaluated. Kidney Int 1984; 25: 591–8.

    Article  PubMed  CAS  Google Scholar 

  51. Lever E, Jaspan JB. Sodium bicarbonate therapy in severe diabetic ketoacidosis. Am J Med 1983; 75: 263–8.

    Article  PubMed  CAS  Google Scholar 

  52. Morris LR, Murphy MB, Kitabchi AE. Bicarbonate therapy in severe diabetic ketoacidosis. Ann Intern Med 1986; 105: 836–40.

    PubMed  CAS  Google Scholar 

  53. Gamba G, Oseguera J, Castrejon M, Gomez-Perez FJ. Bicarbonate therapy in severe diabetic ketoacidosis. A double blind, randomized, placebo controlled trial. Rev Invest Clin 1991; 43: 234–8.

    PubMed  CAS  Google Scholar 

  54. Hale PJ, Crase J, Nattrass M. Metabolic effects of bicarbonate in the treatment of diabetic ketoacidosis. Br Med J 1984; 289: 1035–8.

    Article  CAS  Google Scholar 

  55. Assal JP, Aoki TT, Manzano FM, Kozak GP. Metabolic effects of sodium bicarbonate in management of diabetic ketoacidosis. Diabetes 1974; 23: 405–11.

    PubMed  CAS  Google Scholar 

  56. Bureau MA, Begin R, Berthiaume Y, Shapcott D, Khoury K, Gagnon N. Cerebral hypoxia from bicarbonate infusion in diabetic acidosis. J Pediatrics 1980; 96: 968–73.

    Article  CAS  Google Scholar 

  57. Adrogue HJ, Barrero J, Eknoyan G. Salutary effects of modest fluid replacement in the treatment of adults with diabetic ketoacidosis. JAMA 1989; 262: 2108–13.

    Article  PubMed  CAS  Google Scholar 

  58. Fisher JN, Kitabchi AE. A randomized study of phosphate therapy in the treatment of diabetic ketoacidosis. J Clin Endocrinol Metab 1983; 57: 177–80.

    Article  PubMed  CAS  Google Scholar 

  59. Agarwal R, Knochel JP. Fluid and electrolyte disorders associated with alcoholism and liver disease. In: Kokko JP, Tannen RL (eds). Fluids and electrolytes. Philadelphia: W.B. Saunders, 1996: 449–85.

    Google Scholar 

  60. Fulop M. Alcoholic ketoacidosis. Endocrinol Metab Clinics NA 1993; 22: 209–19.

    CAS  Google Scholar 

  61. Wrenn KD, Slovis CM, Minion GE, Rutkowski R. The syndrome of alcoholic ketoacidosis. Am J Med 1991; 91: 119–28.

    Article  PubMed  CAS  Google Scholar 

  62. Miller PD, Heinig RE, Waterhouse C. Treatment of alcoholic acidosis: the role of dextrose and phosphorus. Arch Intern Med 1978; 138: 67–72.

    Article  PubMed  CAS  Google Scholar 

  63. Harrington JT, Cohen JJ. Metabolic acidosis. In: Cohen JJ, Kassirer JP (eds). Acid-base. Boston: Little, Brown and Company, 1982: 121–225.

    Google Scholar 

  64. Toto RD, Alpern RJ. Metabolic acid-base disorders. In: Kokko JP, Tannen RL (eds). Fluids and electrolytes. Philadelphia: W.B. Saunders, 1996: 201–66.

    Google Scholar 

  65. Rose BD. Metabolic acidosis. In: Clinical Physiology of Acid-Base and Electrolyte Disorders. McGraw-Hill, Inc., 1994: 540–603.

    Google Scholar 

  66. Swerdlow DL, Ries AA. Cholera in the Americas: guidelines for the clinician. JAMA 1992; 267: 1495–9.

    Article  PubMed  CAS  Google Scholar 

  67. Wang F, Butler T, Rabbani GH, Jones PK. The acidosis of cholera: contributions of hyperproteinemia, lactic acidemia, and hyperphosphatemia to an increased serum anion gap. N Engl J Med 1986; 315: 1591–5.

    Article  PubMed  CAS  Google Scholar 

  68. England BK, Mitch WE. Acid-base, fluid, and electrolyte aspects of parenteral nutrition. In: Kokko JP, Tannen RL (eds). Fluids and electrolytes. Philadelphia: W.B. Saunders, 1996: 787–801.

    Google Scholar 

  69. Kushner RF. Total parenteral nutrition-associated metabolic acidosis. J Parenter Enter Nutr 1986; 10: 306–10.

    Article  CAS  Google Scholar 

  70. Velez RJ, Myers B, Guber MS. Severe acute metabolic acidosis (acute beriberi): an avoidable complication of total parenteral nutrition. J Parenter Enteral Nutrition 1985; 9: 216–9.

    Article  CAS  Google Scholar 

  71. Garella S, Lorch JA. Hemodialysis and hemoperfusion for poisoning. In: Henrich WL (ed). Principles and practice of dialysis. Baltimore: Williams and Wilkins, 1994: 375–92.

    Google Scholar 

  72. Wine H, Savitt D, Abuelo JG. Ethylene glycol intoxication. Semin Dial 1994; 7: 338–45.

    Article  Google Scholar 

  73. Pappas SC, Silverman N. Treatment of methanol poisoning with ethanol and hemodialysis. Canadian Med Assoc J 1982; 126: 1391–4.

    CAS  Google Scholar 

  74. Palmisano J, Gruver C, Adams ND. Absence of anion gap metabolic acidosis in severe methanol poisoning: a case report and review of the literature. Am J Kidney Dis 1987; 9: 441–4.

    PubMed  CAS  Google Scholar 

  75. Baud FJ, Galliot M, Astier A, et al. Treatment of ethylene glycol poisoning with intravenous 4methylpyrazole. N Engl J Med 1988; 319: 97–100.

    Article  PubMed  CAS  Google Scholar 

  76. Roberts JR, Hodges J. Clinical Procedures in emergency medicine. Philadelphia: WB Saunders 1985: 1073–4.

    Google Scholar 

  77. Anonymous: Guide to custom dialysis, Vol 3. Lakewwood, CO; REDY Co., Revision E, 1992: 43–8.

    Google Scholar 

  78. Brezis M, Brown RS. An unsuspected cause for metabolic acidosis in chronic renal failure: Sorbent system hemodialysis. Am J Kidney Dis 1985; 6: 425–7

    PubMed  CAS  Google Scholar 

  79. Gabow PA, Anderson RI, Potts DE, Schrier RW. Acid-base disturbances in the salicylate-intoxicated adult. Arch Int Med 1978; 138: 1481–4.

    Article  CAS  Google Scholar 

  80. Richlie DG, Anderson RJ. Contemporary management of salicylate poisoning: When should hemodialysis and hemoperfusion be used? Semin Dial 1996; 9: 257–64.

    Article  Google Scholar 

  81. Madias NE, Cohen JJ. Respiratory acidosis. In: Cohen JJ, Kassirer JP (eds). Acid-base. Boston: Little, Brown and Company, 1982: 307–48.

    Google Scholar 

  82. Slutsky AS. Mechanical ventilation. Chest 1993; 104: 1833–59.

    Article  PubMed  CAS  Google Scholar 

  83. Kilburn KH. Shock, seizures, and coma with alkalosis during mechanical ventilation. Ann Intern Med 1966; 65: 977–84.

    PubMed  CAS  Google Scholar 

  84. Bidani A, Tzouanakis AE, Cardenas VJ, Zwischenberger JB. Permissive hypercapnia in acute respiratory failure. JAMA 1994; 272: 957–62.

    Article  PubMed  CAS  Google Scholar 

  85. Menitove SM, Goldring RM. Combined ventilator and bicarbonate strategy in the management of status asthmaticus. Am J Med 1983; 74: 898–901.

    Article  PubMed  CAS  Google Scholar 

  86. Lakshminarayan S, Sahn SA, Petty TL. Bicarbonate therapy in severe acute respiratory acidosis. Scand J Resp Dis 1973; 54: 128–31.

    Google Scholar 

  87. Brackett NC Jr, Wingo CF, Muren O, Solano JT. Acid-base response to chronic hypercapnia in man. N Engl J Med 1969; 280: 124–30.

    Article  PubMed  Google Scholar 

  88. Sonett J, Pagani FD, Baker LS, et al. Correction of intramyocardial hypercarbic acidosis with sodium bicarbonate. Circ Shock 1994; 42: 163–73.

    PubMed  CAS  Google Scholar 

  89. Wetterberg T, Sjoberg T, Steen S. Effects of buffering in hypercapnia and hypercapnic hypoxemia. Acta Anaesthesiol Scand 1993; 37: 343–9.

    Article  PubMed  CAS  Google Scholar 

  90. Bear R, Goldstein M, Phillipson E, Ho M, Hammeke M, Feldman R, et al. Effect of metabolic alkalosis on respiratory function in patients with chronic obstructive lung disease. CMAJ 1977; 117: 900–3.

    CAS  Google Scholar 

  91. Miller PD, Berns AS. Acute metabolic alkalosis perpetuating hypercarbia. A role for acetazolamide in chronic obstructive pulmonary disease. JAMA 1977; 238: 2400–1.

    Article  PubMed  CAS  Google Scholar 

  92. Harrington JT, Kassirer JP. Metabolic alkalosis. In: Cohen JJ, Kassirer JP (eds). Acid/Base. Boston, Little, Brown and Company, 1982: 227–306.

    Google Scholar 

  93. Jacobson HR. Chloride-responsive alkalosis. In: Seldin DW, Giebisch G (eds). The regulation of acid-base balance. New York, Raven Press 1989: 431–58.

    Google Scholar 

  94. Altmann P. Clinical manifestations of electrolyte and acid-base disorders. In: Arieff AI, DeFronzo RA (eds). Fluid, electrolyte, and acid-base disorders. New York, Churchill Livingston Inc., 1995: 527–72.

    Google Scholar 

  95. Lubasch GB, Cohen BD, Young CW, Siverman GM, Rubin AL. Severe metabolic alkalosis with neurologic abnormalities. New Engl J Med 1958: 258; 1050–2.

    Article  Google Scholar 

  96. Grace WJ, Barr DP. Complications of alkalosis. Am J Med 1948: 4; 331–7.

    Article  PubMed  CAS  Google Scholar 

  97. van Ypersele de Strihou C, Frans A. The respiratory response to chronic metabolic alkalosis and acidosis in disease. Clin Sci Mol Med 1973: 45: 439–48.

    PubMed  Google Scholar 

  98. Javaheri S, Kazemi H. Metabolic alkalosis and hypo-ventilation in humans. Am Rev Resp Dis 1987: 136: 1011–6.

    Article  PubMed  CAS  Google Scholar 

  99. Garella S. Clinical acid/base disorders. In: Cameron S, Davison AM, Grunfeld JP, Kerr D, Ritz E (eds). Oxford Textbook of Clinical Nephrology. Oxford, New York, Tokyo, Oxford University Press, 1992: 917–65.

    Google Scholar 

  100. Wagner CW, Nesbit RR Jr, Mansberger AR Jr. Treat ment of metabolic alkalosis with intravenous hydrochloric acid. South Med J 1979; 72: 1241–5.

    Article  PubMed  CAS  Google Scholar 

  101. Rowlands BJ, Tindall SF, Elliott DJ. The use of hydrochloric acid and cimetidine to reverse severe metabolic alkalosis. Postgrad Med J 1978; 54: 123–6.

    Article  Google Scholar 

  102. Knutsen OH. New method for administration of hydrochloric acid in metabolic alkalosis. Lancet 1983; i: 963–6.

    Google Scholar 

  103. Seldin DW, Welt LG, Cort JH. The role of sodium salts and adrenal steroids in the production of hypokalemic alkalosis. Yale J Biol Med 1956; 29: 229–47.

    PubMed  CAS  Google Scholar 

  104. Bushinsky DA, Gennari FJ. Life-threatening hyperkalemia induced by arginine. Ann Int Med 1978; 89: 632–4.

    PubMed  CAS  Google Scholar 

  105. Swartz RD, Jacobs F. Modified dialysis for metabolic alkalosis. Ann Int Med 1978; 88: 432–3.

    Google Scholar 

  106. Ayus JC, Olivero JJ, Adrogué HJ. Alkalemia associated with renal failure. Correction by hemodialysis with low-bicarbonate dialysate. Arch Int Med 1980; 140: 513–5.

    Article  CAS  Google Scholar 

  107. Roberts M, Daugirdas JT. REDY sorbent hemodialysis. In: Handbook of dialysis. Daugirdas JT, Ing TS (eds). Boston/Toronto, Little, Brown and Company, 1988: 146–63.

    Google Scholar 

  108. Shapiro WB. REDY sorbent hemodialysis system. In: Dialysis Therapy, 2nd edition. Nissenson AR, Fine RN (eds). Philadelphia, Hanley and Belfus, 1992: 146–9.

    Google Scholar 

  109. Fraley DS, Adler S, Bruns F. Life-threatening metabolic alkalosis in a comatose patient. South Med J 1979; 72; 1024–5.

    Article  PubMed  CAS  Google Scholar 

  110. Grigor KC, Blair JJ, Hutchison JRS. The effect of acetazolamide on post-perfusion metabolic alkalosis. Br J Anesth 1971; 43: 352–61.

    Article  CAS  Google Scholar 

  111. Schwartz WB, Brackett NC Jr, Cohen JJ. The response of extracellular hydrogen ion concentration to graded degrees of chronic hypercapnia: the physiologic limits of defense of pH. J Clin Invest 1965; 44: 291–301

    Article  PubMed  CAS  Google Scholar 

  112. Schwartz WB, Cohen II. The nature of the renal response to chronic disorders of acid-base equilibrium. Am J Med 1978; 64: 417–28.

    Article  PubMed  CAS  Google Scholar 

  113. Tannen RL, Hamid B. Adaptive changes in renal acidification in response to chronic respiratory acidosis. Am J Physiol 1985; 248: F492–9.

    PubMed  CAS  Google Scholar 

  114. van Ypersele de Strihou C, Brasseur L, De Cononck J. The ‘carbon dioxide response curve’ for chronic hypercapnia in man. N Engl J Med 1966; 275: 117–22.

    Article  Google Scholar 

  115. Kassirer JP, London AM, Goldman DM, Schwartz WB. On the pathogenesis of metabolic alkalosis in hyperaldosteronism. Am J Med 1970; 49: 306–15.

    Article  PubMed  CAS  Google Scholar 

  116. Seldin DW, Welt LG, Cort JH. The role of sodium salts and adrenal steroids in the production of hypokalemic alkalosis. Yale J Biol Med 1956; 29: 229–47.

    PubMed  CAS  Google Scholar 

  117. Hene RJ, Koomans HA, Dorhout Mees EJ, v.d. Stolpe A, Verhoef GE, Boer P. Correction of hypokalemia in Bartter’s syndrome by enalapril. Am J Kidney Dis 1987; 9: 200–5.

    PubMed  CAS  Google Scholar 

  118. Vinci JM, Gill JR, Bowden RE, Pisano JJ, Izzo JL Jr, Radfar N, Taylor AA, Zusman RM, Bartter FC, Keiser HR. The kallikrein-kinin system in Bartter’s syndrome and its response to prostaglandin synthetase inhibition. J Clin Invest 1978; 61: 1671–82.

    Article  PubMed  CAS  Google Scholar 

  119. Garella S, Chazan JA, Cohen JJ. Saline-resistant metabolic alkalosis or `chloride-wasting nephropathy. ’ Ann Int Med 1970; 73: 31–8.

    PubMed  CAS  Google Scholar 

  120. Baehler RW, Work J, Kotchen TA, McMorrow G, Guthrie G. Studies in the pathogenesis of Bartter’s syndrome. Am J Med 1980; 69: 933–88.

    Article  PubMed  CAS  Google Scholar 

  121. Lenfant C, Sullivan K. Adaptation to high altitude. N Engl J Med 1971; 284: 1298–309.

    Article  PubMed  CAS  Google Scholar 

  122. Lucius H, Galenbeck H, Kleine HO, Fabel H, Bartels H. Respiratory functions, buffer system and electrolyte concentrations of blood during human pregnancy. Respir Physiol 1970; 9: 311–7.

    Article  PubMed  CAS  Google Scholar 

  123. Ponten U. Consecutive acid-base changes in blood, brain tissue and cerebrospinal fluid during respiratory acidosis and baseosis. Acta Neurol Scand 1966; 42: 455–71.

    Article  PubMed  CAS  Google Scholar 

  124. Ayres SM, Grace WJ. Inappropriate ventilation and hypoxemia as causes of cardiac arrhythmias. The control of arrhythmias without antiarrhythmic drugs. Am Med 1969; 46: 495–505.

    Article  CAS  Google Scholar 

  125. Magarian GJ. Hyperventilation syndromes: Infrequently recognized common expressions of anxiety and stress. Medicine 1982; 61: 219–36.

    Article  PubMed  CAS  Google Scholar 

  126. Wilson RF, Gibson D, Percinel AK, et al. Severe alkalosis in critically ill surgical patients. Arch Surg 1972; 105: 197–202.

    Article  PubMed  CAS  Google Scholar 

  127. Christensen MS. Acid-base changes in cerebrospinal fluid and blood and blood volume changes following prolonged hyperventilation in man. Br J Anaesth 1974; 46: 348–57.

    Article  PubMed  CAS  Google Scholar 

  128. Adrogue HJ, Madias NE. Management of life-threatening acid-base disorders. N Engl J Med 1998; 338: 26–34.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Spital, A., Garella, S. (1998). Correction of acid-base derangements. In: Critical Care Nephrology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5482-6_27

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5482-6_27

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6306-7

  • Online ISBN: 978-94-011-5482-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics