Skip to main content

Management of desmoid tumours including a case report of toremifene

  • Chapter
The Teaching Cases from Annals of Oncology
  • 93 Accesses

Abstract

A previously fit 17-year-old female presented with a swelling in the left loin region. This was associated with episodes of moderately severe pain of a constant nature, but no other symptoms. Clinical examination revealed a smooth, fixed mass in the left upper abdominal quadrant. A CT scan (Fig. 1) showed an extensive left-sided retroperitoneal soft-tissue mass extending posteriorly between the psoas muscle and vertebrae. The mass was in close apposition to the left side of the abdominal aorta, and encased almost the entire circumference of the common iliac artery and part of the corresponding vein on that side. There was infiltration of the mesentery and psoas muscle with obstruction of the left ureter and a grossly hydronephrotic kidney (Fig. 2). An IVU confirmed the latter finding, though a DPTA scan demonstrated preservation of renal function (differential function approx. 50:50).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Muller J. Ueber den feirnern bau and formen der krankhaften geschwulste. Berlin: G Reimer 1838; 60.

    Google Scholar 

  2. Gardner EJ. Am J Human Genetics 1951; 3: 167.

    CAS  Google Scholar 

  3. MacAdam WAF, Goligher JC. The occurrence of desmoids in patients with familial polyposis coli. Br J Surg 1970; 57: 618–31.

    Article  Google Scholar 

  4. Naylor EW, Gardner EJ, Richards RC. Desmoid tumours and mesenteric fibromatosis in Gardners syndrome. Arch Surg 1979; 114: 1181–5.

    Article  CAS  PubMed  Google Scholar 

  5. Richards RC, Rogers SW, Gardner EJ. Spontaneous mesenteric fibromatosis in Gardner’s syndrome. Cancer 1981; 47: 597–601.

    Article  CAS  PubMed  Google Scholar 

  6. Bulow S. Incidence of associated diseases in FPC. Semin Surg Oncol 1987; 3: 84–7.

    Article  CAS  PubMed  Google Scholar 

  7. Reitamo JJ, Scheinin TM, Hayry P. The desmoid syndrome. Am J Surg 1986; 151: 230–7.

    Article  CAS  PubMed  Google Scholar 

  8. Cole NM, Guiss LW. Arch Surg 1969; Chicago 98: 530.

    Article  CAS  PubMed  Google Scholar 

  9. Rokitansky KW (1880). Cited in Stewart MJ, Mouat TB. Br J Surg 1924; 12: 355.

    Article  Google Scholar 

  10. Easter EW, Halasz NA. Recent trends in the management of desmoid tumours. Summary of 19 cases and review of the literature. Ann Surg 1989; 210: 765–9.

    Article  CAS  PubMed  Google Scholar 

  11. Lipschutz A, Jadrijevic D, Girardi S et al. Antifibromatogenic potency of 9 — fluoro derivatives of progesterone. Nature 1956; 178: 139.

    Article  Google Scholar 

  12. Biron P, Meckenstock R, Bobin JY et al. Presence of hormone receptors on desmoid tumours (Meeting abstract). Proc Am Meet Am Soc Clin Oncol 1990; 9: 1107.

    Google Scholar 

  13. Das Gupta TK, Brasfield RD, O’Hara J. Extra-abdominal desmoids — a clinico-pathological study. Ann of Surgery 1969; 170: 109–22.

    Article  CAS  Google Scholar 

  14. Kofoed H, Kamby C, Anagnostaki L. Aggressive fibromatosis. Surg Gynae & Obstetrics 1985; 160: 124–7.

    CAS  Google Scholar 

  15. McKinnon JG, Neifeld JP, Kay S et al. Management of desmoid tumours. Surg Gynae Obst 1989; 169: 104–6.

    CAS  Google Scholar 

  16. Pack GT, Erhlich HE. Neoplasms of the anterior abdominal wall with special consideration of desmoid tumours: Experience with 391 cases and a collective review of the literature. Int Abst Surg 1944; 79: 177–84.

    Google Scholar 

  17. Kiel KD, Suit HD. Radiation therapy in the treatment of aggressive fibromatoses. Cancer 1984; 54: 2051–5.

    Article  CAS  PubMed  Google Scholar 

  18. Plukker JTh, van Oort I, Vermey A et al. Aggressive fibromatosis (non-familial desmoid tumour): Therapeutic problems and role of adjuvant radiotherapy. Br J Surg 1995; 82: 510–4.

    Article  CAS  PubMed  Google Scholar 

  19. Keur R, Bartelink H. The role of radiotherapy in the treatment of desmoid tumours. Radiother Oncol 1986; 7: 1–5.

    Article  Google Scholar 

  20. Greenberg HM, Goebel R, Weichselbaum RR et al. Radiation therapy in the treatment of aggressive fibromatoses. Int J Radiat Oncol Biol Phys 1983; 7: 305–10.

    Article  Google Scholar 

  21. Leibel SA, Wara WM, Hill DR et al. Desmoid tumours: Local control and patterns of relapse following radiation therapy. Int J Radiat Oncol Biol Phys 1983; 9: 1167–71.

    Article  CAS  PubMed  Google Scholar 

  22. Belliveau P, Graham AM. Mesenteric desmoid tumour in Gardners syndrome treated by Sulindac. Dis Col Rectum 1984; 27: 53–4.

    Article  CAS  Google Scholar 

  23. Tsukada K, Church JM, Jagelman DG et al. Non-cytotoxic drug therapy for intra-abdominal desmoid tumour in patients with FAP. Dis Col Rectum 35: 29–33.

    Google Scholar 

  24. Kinzbrunner B, Ritter S, Domingo J et al. Remission of rapidly growing desmoid tumours after tamoxifen therapy. Cancer 1983; 52: 2201–4.

    Article  CAS  PubMed  Google Scholar 

  25. Proctor H, Singh L, Baum M. Response of multi-centric desmoid tumours to tamoxifen. Br J Surg 1987; 74: 401.

    Article  Google Scholar 

  26. Mukherjee A, Malcolm A, De La Hunt M, Neal DE. Pelvic fibromatosis (desmoid) — treatment with steroids and tamoxifen. BrJ Urol 1995; 75: 559–60.

    Article  CAS  Google Scholar 

  27. Nolvadex Adjuvant Trial Organisation. Controlled trial of tamoxifen as a single adjuvant agent in the management of early breast cancer. Br J Cancer 1987; 57: 608.

    Google Scholar 

  28. Early Breast Cancer triallists Collaborative Group. Effects of adjuvant tamoxifen and of cytotoxic therapy on the mortality in early breast cancer: An overview of 61 randomised trials amongst 28,896 women. Lancet 1992; 339: 1-15; 71–5.

    Google Scholar 

  29. Colletta A, Wakefield LM, Howell FV et al. Anti-oestrogens induce the secretion of active transforming growth factor beta from human foetal fibroblasts. Br J Cancer 1990; 62: 405–9.

    Article  CAS  PubMed  Google Scholar 

  30. Butta A, Maclennan K, Flanders KC et al. Induction of transforming growth factor beta in human breast cancer in vivo following tamoxifen treatment. Cancer Res 1992; 52: 4261–2.

    CAS  PubMed  Google Scholar 

  31. Brooks MD, Ebbs SR, Colletta AA et al. Desmoid tumours treated with triphenylethylenes. Eur J Cancer 1992; 28: 1014–8.

    Article  Google Scholar 

  32. Ebbs SR, Roberts J, Baum M. Response to toremifene therapy in tamoxifen failed patients with breast cancer. J Steroid Biochem 1990; 36: 239.

    Google Scholar 

  33. Benson JR, Baum M. Breast cancer, desmoid tumours and Familial Adenomatous Polyposis — a unifying hypothesis. The Lancet 1993; 342: 848–50.

    Article  CAS  Google Scholar 

  34. Lim CL, Walker MJ, Menta RR et al. Oestrogen and antioestrogen binding sites in desmoid tumours. Eur J Cancer Clin Oncol 1986; 22: 583–7.

    Article  CAS  PubMed  Google Scholar 

  35. Lynch H, Fitzgibbons R, Chong S et al. Use of doxorubicin and dacarbazine for the management of unresectable intra-abdominal desmoid tumours in Gardner’s syndrome. Dis Colon Rectum 1994; 37: 260–7.

    Article  CAS  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Benson, J.R., Mokbel, K., Baum, M. (1997). Management of desmoid tumours including a case report of toremifene. In: Souhami, R.L. (eds) The Teaching Cases from Annals of Oncology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5456-7_29

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5456-7_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-4117-8

  • Online ISBN: 978-94-011-5456-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics