Skip to main content

The management of non-seminomatous germ cell tumours (GCT)

  • Chapter
The Teaching Cases from Annals of Oncology

Abstract

In April 1992, a 40-year-old TV assistant presented to his general practitioner with a two-day history of swelling of the left testicle. He had had no previous local injury or systemic symptoms apart from possible mild fever. Clinical examination revealed tenderness, swelling and increased temperature of the left gonad, but no separate mass. His family and past medical histories were unremarkable. He was on no medication.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Einhorn LH. Treatment of testicular cancer: A new and improved model, J Clin Oncol 1990; 8:1877–81.

    Google Scholar 

  2. Droz JP, Kramar A, Rey A. Prognostic factors in metastatic disease. Sem Oncol 1992; 19:181–9.

    CAS  Google Scholar 

  3. Medical Research Council Working Party on testicular tumours. Prognostic factors in advanced non-seminomatous germ-cell testicular tumours: Results of a multicenter study. Lancet 1985; I:8–11.

    Google Scholar 

  4. Mostofi FK, Sibin LH. Histological typing of testis tumors. International classification of tumors, No. 16. Geneva, World Health Organization, 1977.

    Google Scholar 

  5. Husband J. Advances in tumour imaging. In Horwich A (ed): Testicular cancer: Investigation and management. Chapman and Hall Medical: New York 1991; 2:15–31.

    Google Scholar 

  6. Tait D, Peckham MJ, Hendry WF et al. Postchemotherapy surgery in advanced non-seminomatous germ cell tumours: The significance of histology with particular reference to differentiated (mature) teratoma. Br J Cancer 1984; 50:601–9.

    Article  CAS  PubMed  Google Scholar 

  7. Williams SD, Stablein DM, Einhorn LH et al. Immediate adjuvant chemotherapy versus observation with treatment at relapse in pathological stage II testicular cancer. N Engl J Med 1987; 317:1433–8.

    Article  CAS  PubMed  Google Scholar 

  8. Donahue JP, Thornhill JA, Foster RS et al. Retroperitoneal lymphadenectomy for clinical stage A testis cancer (1965-1989): Modifications of technique and impact on ejaculation. J Urol 1993; 149:137–43.

    Google Scholar 

  9. Read G, Stenning SP, Cullen MH et al. Medical Research Council prospective study of surveillance for stage I testicular teratoma. J Clin Oncol 1992; 10:1762–8.

    CAS  PubMed  Google Scholar 

  10. Cullen MH on behalf of the Medical Research Council (MRC) Testicular Tumour Working Party. Short course adjuvant chemotherapy in high risk stage I non seminomatous germ cell tumours of the testis (NSGCTT): An MRC study report. Proc III Germ Cell Tumour Conference 1993; 3:47 (Abstract).

    Google Scholar 

  11. Mead GM, Stenning SP, Parkinson MC et al. The Second Medical Research council study of prognostic factors in non-seminomatous germ cell tumors. J Clin Oncol 1992; 10:85–94.

    CAS  PubMed  Google Scholar 

  12. Williams SD, Birch B, Einhorn LH et al. Treatment of disseminated germ cell tumors with cisplatin, bleomycin and either vinblastine or etoposide. N Engl J Med 1987; 316:1435–40.

    Article  CAS  PubMed  Google Scholar 

  13. Einhorn LH, Williams SD, Loehrer PJ et al. Evaluation of optimal duration of chemotherapy in favourable-prognosis disseminated germ cell tumors: A Southeastern Cancer Study Group protocol. J Clin Oncol 1989; 7:387–91.

    CAS  PubMed  Google Scholar 

  14. Bejorin DF, Sarosdy MF, Pfister DG et al. Randomized trial of etoposide and cisplatin versus etoposide and carboplatin in patients with good-risk germ cell tumors: A multiinstitutional study. J Clin Oncol 1993; 11:598–606.

    Google Scholar 

  15. Levi JA, Raghavan D, Harvey V et al. The importance of bleomycin in combination chemotherapy for good-prognosis germ cell carcinoma. J Clin Oncol 1993; 11:1300–5.

    CAS  PubMed  Google Scholar 

  16. Paz-Ares L, Kaye SB. Intensive treatment schedules. Proc III Germ Cell Conference 1993; 3:56.

    Google Scholar 

  17. Einhorn LH, Williams SD, Mandelbaum I et al. Surgical resection in disseminated testicular cancer following chemotherapeutic cytoreduction. Cancer 1981; 48:904–10.

    Article  CAS  PubMed  Google Scholar 

  18. Paz-Ares L, Lianes P, Diaz-Puente M et al. Late relapses (LR) in malignant germ cell tumors (MCGT) treated with cisplatinbased chemotherapy. Proc Am Ass Cancer Res 1992; 34:222 (Abstract).

    Google Scholar 

  19. Toner CG, Panicek DM, Heelan RT et al. Adjuntive surgery after chemotherapy for nonseminomatous germ cell tumors: Recommendations for patient selection. J Clin Oncol 1990; 8:1683–94.

    CAS  PubMed  Google Scholar 

  20. Hansen SW, Helweg-Larsen S, Trojaborg W. Long-term neurotoxicity in patients treated with cisplatin, vinblastine and bleomycin for metastatic germ cell cancer. J Clin Oncol 1989; 7:1457–61.

    CAS  PubMed  Google Scholar 

  21. Hansen SW, Groth S, Daugaard G et al. Long term side-effects on renal function and blood pressure of treatment with cisplatin, vinblastine and bleomycin in patients with germ cell cancer. J Clin Oncol 1988; 6:1728–31.

    CAS  PubMed  Google Scholar 

  22. Boyer M, Raghavan D. Toxicity of treatment of germ cell tumors. Sem Oncol 1992; 19:128–42.

    CAS  Google Scholar 

  23. Fossa SD, Kreuser ED, Roth GJ et al. Long-term side effects after treatment of testicular cancer. Prog Clin Biol Res 1988; 357:321–30.

    Google Scholar 

  24. von der Maase H, Rorth M, Walbom-Jorgesen S et al. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer. A study 27 cases in 500 patients. Br Med J 1986; 293:1398–401.

    Google Scholar 

  25. Pedersen-Bjergaard J, Daugaard G, Hansen ST et al. Increased risk of myelodisplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ cell tumours. Lancet 1991:338:359–63.

    Article  CAS  PubMed  Google Scholar 

  26. Rodriguez E, Mathew S, Reuter VE et al. Cytogenetic analysis of 124 prospectively ascertained male germ cell tumors. Cancer Res 1992; 52:2285–91.

    CAS  PubMed  Google Scholar 

  27. Harding MJ, Paul J, Gillis CR et al. Management of malignant teratoma: Does referral to a specialist unit matter? Lancet 1993; 341:999–1002.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Paz-Ares, L., Lianes, P., Cortes-Funes, H. (1997). The management of non-seminomatous germ cell tumours (GCT). In: Souhami, R.L. (eds) The Teaching Cases from Annals of Oncology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5456-7_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5456-7_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-4117-8

  • Online ISBN: 978-94-011-5456-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics