Abstract
Antibodies to DNA can be found in the circulation of the majority of patients with Systemic Lupus Erythematosus (SLE). They are quite specific for this disease, which makes their detection an important diagnostic aid to the clinician. Fluctuations in the level of anti-dsDNA in an individual patient generally parallel the clinical status of that patient. Furthermore, the presence of anti-dsDNA may precede the diagnosis of SLE by more than a year.
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Abbreviations
- SLE:
-
systemic lupus erythematosus
- ELISA:
-
enzyme linked immunosorbent assay
- PEG:
-
polyethylene glycol
- IFT:
-
immunofluorescence technique
- PBS:
-
phosphate buffered saline
- BSA:
-
bovine serum albumin
- HRP:
-
horse radish peroxidase
- RIA:
-
radioimmuno assay
- FITC:
-
fluorescein isothiocyanate
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© 1993 Springer Science+Business Media Dordrecht
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Smeenk, R. (1993). Measurement of antibodies to DNA. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_8
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DOI: https://doi.org/10.1007/978-94-011-5444-4_8
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