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Myositis-associated antigens. Aminoacyl-tRNA synthetases Jo-1, PL-7, PL-12, EJ, and OJ

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Manual of Biological Markers of Disease

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Abstract

In 1980, Nishikai and Reichlin recognized a precipitating system by Ouchterlony immunodiffusion, labeled Jo-1 after the prototype patient, that was apparently specific for myositis [1]. In 1983, using 32P-labeled HeLa cells or mouse Friend erythroleukemia cells as a source of antigen, Rosa et al. recognized that a tRNAhis was immunoprecipitated by anti-Jo-1 -containing sera from myositis patients [2]. Shortly thereafter, Mathews and Bernstein showed that a protein of Mr 50,000 was immunoprecipitated from 35S-labeled HeLa cell extracts by anti-Jo-l-containing sera, and that the enzyme which joins histidine to tRNAhis, histidyl-tRNA synthetase (HRS), was inhibited by these sera [3].

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Abbreviations

Jo-1 = HRS:

histidyl-tRNA synthetase

PL-7 = TRS:

threonyl-tRNA synthetase

PL-12 = ARS:

alanyl-tRNA synthetase

EJ = GRS:

glycyl-tRNA synthetase

OJ = IRS:

isoleucyl-tRNA synthetase

References

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Author information

Authors and Affiliations

  1. Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Paul Plotz

  2. Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA

    Ira Targoff

Authors
  1. Paul Plotz
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  2. Ira Targoff
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Editor information

Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. Van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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© 1994 Springer Science+Business Media Dordrecht

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Plotz, P., Targoff, I. (1994). Myositis-associated antigens. Aminoacyl-tRNA synthetases Jo-1, PL-7, PL-12, EJ, and OJ. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_17

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  • DOI: https://doi.org/10.1007/978-94-011-5444-4_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-4243-4

  • Online ISBN: 978-94-011-5444-4

  • eBook Packages: Springer Book Archive

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