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The RF antigen

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Manual of Biological Markers of Disease

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Abstract

It is now more than 70 years since rheumatoid factors (RFs) were discovered and nearly 50 years since they were first associated with rheumatoid arthritis (RA) [1, 2]. During that time, a vast amount of work has been done on the incidence, nature and specificity of RF in many laboratories. These studies established that RFs react with determinants expressed on the Fc of IgG from human and other primates [3]. Thus the term RF is generally used to describe autoantibodies to IgG Fc. The term antiglobulins (which has been used as a synonym for RF in some studies) refers to any antibody reactive with determinants other than those on the Fc of IgG, or on immunoglobulin isotypes, such as IgE and IgA [4, 5]. Some RFs are also known to cross-react with other non-IgG related antigenic determinants [6].

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Abbreviations

Ag:

antigen

Cγ:

IgG heavy chain constant region

CH :

Ig heavy chain constant region domain

CL :

light chain constant region domain

Cμ:

IgM constant region

DAG:

diacylglycerol

DEAE:

diethyl amino ethyl

ELISA:

enzyme-linked immunosorbent assay

ER:

endoplasmic reticulum

Fab:

fragment antigen binding

Fc:

fragment crystalline

FcγR:

IgG Fc receptor;

Gm:

IgG allotypic marker

HC:

heavy chain

Ig:

immunoglobulin

IP3:

inositol 1,4,5-triphosphate

kD:

kilo dalton

LC:

light chain

MHC:

major histocompatibility complex

mIg:

membrane-bound immunoglobulin

mRNA:

messenger RNA

PIP2:

phosphatidyl inositol 4,5-biphosphate

PKC:

phosphokinase C

PLC:

phospholipase C

RA:

rheumatoid arthritis

RF:

rheumatoid factor

RER:

rough endoplasmic reticulum

RIA:

radio-immunoassay

S:

Svedberg units (a unit for measuring sedimentation coefficient of molecules)

SPA:

Staphylococcal protein A

SRBC:

sheep red blood cell

VH :

immunoglobulin heavy chain variable region domain

VL :

immunoglobulin light chain variable region domain

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Authors and Affiliations

  1. Kennedy Institute of Rheumatology, 6 Bute Gardens, Hammersmith, London, W6 7DW, UK

    Rizgar A. Mageed

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  1. Rizgar A. Mageed
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Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. Van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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© 1994 Springer Science+Business Media Dordrecht

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Mageed, R.A. (1994). The RF antigen. In: Van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5444-4_12

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  • DOI: https://doi.org/10.1007/978-94-011-5444-4_12

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