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Prevention and treatment of cytomegalovirus (CMV) disease

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Late Graft Loss

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 28))

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Abstract

Cytomegalovirus (CMV) is the most important of the 8 presently-recognized human herpes viruses in terms of its pathogenic potential in immunocompromised hosts. CMV is responsible for substantial morbidity after solid organ and bone marrow transplantation [1,2] and is the most common cause of ‘opportunistic’ viral disease in HIV/AIDS [3]. Prevention and treatment of CMV disease is clearly a high priority.

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References

  1. Peterson PK, Balfour HH Jr, Fryd DS, Ferguson RM, Simmons RL. Fever in renal transplant recipients: causes, prognostic significance and changing patterns at the University of Minnesota Hospital. Am. J. Med. 1981; 71: 345–351.

    Article  PubMed  CAS  Google Scholar 

  2. Neiman PE, Reeves W, Ray G et al. A prospective analysis of interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts. J. Infect. Dis. 1977; 136: 754–767.

    Article  PubMed  CAS  Google Scholar 

  3. Selik RM, Chu S Y, Ward JW. Trends in infectious diseases and cancers among persons dying of HIV infection in the United States from 1987 to 1992. Ann. Intern. Med. 1995; 123: 933–936.

    PubMed  CAS  Google Scholar 

  4. Walter EA, Greenberg PD, Gilbert MJ et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 1995; 333: 1038–1044.

    Article  PubMed  CAS  Google Scholar 

  5. Prentice HG, Gluckman E, Powles RL et al. Impact of long-term acyclovir on cytomegalovirus infection and survival after allogeneic bone marrow transplantation. Lancet 1994; 343: 749–753.

    Article  PubMed  CAS  Google Scholar 

  6. Balfour HH Jr, Chace BA, Stapleton JT, Simmons RL, Fryd DS. A randomized, placebo-controlled trial of oral acyclovir for the prevention of cytomegalovirus disease in recipients of renal allografts. N. Engl. J. Med. 1989; 320: 1381–1387.

    Article  PubMed  Google Scholar 

  7. Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 1992; 358: 162–164.

    Article  PubMed  CAS  Google Scholar 

  8. Goodrich JM, Bowden RA, Fisher L, Keller C, Schoch G, Meyer JD. Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant. Ann. Intern. Med. 1993; 118: 173–178.

    PubMed  CAS  Google Scholar 

  9. Spector SA, McKinley GF, Lalezari JP et al. Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. N. Engl. J. Med. 1996; 334: 1491–1497.

    Article  PubMed  CAS  Google Scholar 

  10. Weller S, Blum MR, Doucette M et al. Pharmacokinetics of the acyclovir prodrug valaciclovir after escalating single- and multiple-dose administration to normal volunteers. Clin. Pharmacol. Ther. 1993; 54: 595–605.

    Article  PubMed  CAS  Google Scholar 

  11. Singh N, Yu VL, Mieles L, Wagener MM, Miner RC, Gayowski T. High-dose acyclovir compared with short-course preemptive ganciclovir therapy to prevent cytomegalovirus disease in liver transplant recipients: a randomized trial. Ann. Intern. Med. 1994; 120: 375–381.

    PubMed  CAS  Google Scholar 

  12. Bowen EF, Wilson P, Atkins M et al. Natural history of untreated cytomegalovirus retinitis. Lancet 1995; 346: 1671–1673.

    Article  PubMed  CAS  Google Scholar 

  13. Freitas VR, Fraser-Smith EB, Matthews TR et al. Increased efficacy of ganciclovir in combination with foscarnet against cytomegalovirus and herpes simplex virus type 2 in vitro and in vivo. Antiviral Res. 1989; 112: 205–212.

    Article  Google Scholar 

  14. Manischewitz JF, Quinnan GV, Lane HC et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro. Antimicrob. Agents Chemother. 1990; 34: 373–375.

    Article  CAS  Google Scholar 

  15. Studies of Ocular Complications of AIDS Research Group in Collaboration with the AIDS Clinical Trials Group. Combination foscarnet and ganciclovir therapy vs monotherapy for the treatment of relapsed cytomegalovirus retinitis in patients with AIDS. Arch. Opthalmol. 1996; 114: 23–32.

    Article  Google Scholar 

  16. Lopez C, Simmons RL, Mauer SM, Najarian JS, Good RA, Gentry S. Association of renal allograft rejection with virus infections. Am. J. Med. 1974; 56: 280–289.

    Article  PubMed  Google Scholar 

  17. Pouteil-Noble C, Ecochard R, Landrivon G et al. Cytomegalovirus infection — an etiological factor for rejection? A prospective study in 242 renal transplant patients. Transplantation 1993; 55: 851–857.

    Article  PubMed  CAS  Google Scholar 

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© 1997 Springer Science+Business Media Dordrecht

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Balfour, H.H. (1997). Prevention and treatment of cytomegalovirus (CMV) disease. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Late Graft Loss. Transplantation and Clinical Immunology, vol 28. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5434-5_21

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  • DOI: https://doi.org/10.1007/978-94-011-5434-5_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6286-2

  • Online ISBN: 978-94-011-5434-5

  • eBook Packages: Springer Book Archive

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