Abstract
Because of the large amount of lymphoid tissue in the small bowel, its immunogenicity is much greater than that of solid organs. In addition, graft-versus-host (GVH) disease has been identified as a major problem in animal experiments [1]. Alexis Carrel demonstrated the technical feasibility of intestinal transplantation 90 years ago and correctly predicted rejection to be the main obstacle [2]. Almost 70 years later the first series of successful small bowel transplants in animals was reported by Lillehei [3]. The same author published a clinical case of intestinal transplantation in 1967 [4], although the two first cases of intestinal transplantation had already been performed by Deterling and colleagues at the Boston Floating Hospital in 1964 [5]. Neither of these cases, however, has been reported in detail. Since the results of intestinal transplantations performed so far have been highly dependent on the type of immunosuppression used, it seems reasonable to break down the entire series of intestinal transplants according to immunosuppression.
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Margreiter, R. (1997). Results of intestinal transplantation. In: Collins, G.M., Dubernard, J.M., Land, W., Persijn, G.G. (eds) Procurement, Preservation and Allocation of Vascularized Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5422-2_34
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DOI: https://doi.org/10.1007/978-94-011-5422-2_34
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