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Pharmacological agents in organ preservation

  • Chapter
Procurement, Preservation and Allocation of Vascularized Organs

Abstract

Pharmacological agents have played only a minor role in clinical organ preservation. Several decades of intensive research on the pathophysiology of hypothermic ischaemia led to the introduction of numerous pharmacological agents that were shown to ameliorate this condition, but few of these promising agents are currently used in clinical organ procurement. Research efforts have been directed primarily toward the development of flush solutions. The primary research effort was to overcome cellular swelling. Both Collins’ solution [1] and the University of Wisconsin solution [2] contain impermeant sugars and specific electrolytes designed to combat tissue swelling noted during cold storage. Most flush solutions also contain a mixture of additives designed to interfere with various ischaemic processes. The use of these agents remains empirical and the significance of each component has not been ascertained.

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Authors
  1. David Anaise
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Editor information

Editors and Affiliations

  1. Department of Transplantation, California Pacific Medical Center, San Francisco, California, USA

    G. M. Collins

  2. Transplantation Pavillon V, HĂ´pital Edouard Herriot, Lyon, France

    J. M. Dubernard

  3. Division of Transplant Surgery, Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany

    W. Land

  4. Eurotransplant Foundation, Leiden, The Netherlands

    G. G. Persijn

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Anaise, D. (1997). Pharmacological agents in organ preservation. In: Collins, G.M., Dubernard, J.M., Land, W., Persijn, G.G. (eds) Procurement, Preservation and Allocation of Vascularized Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5422-2_16

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  • DOI: https://doi.org/10.1007/978-94-011-5422-2_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6280-0

  • Online ISBN: 978-94-011-5422-2

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