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Cysteine and Serine Proteases in Duodenal Ulcer

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Cell Injury and Protection in the Gastrointestinal Tract

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Abstract

Cysteine proteases (cathepsin B and L: CATB and CATL, respectively) are involved in gastric mucosal injury while urokinase-and tissue-type plasminogen activators (serine proteases; UPA, TPA) and their inhibitor PAI-1 may play a part in the pathogenesis of duodenal ulcer disease (DU).

The aim of this study was to determine CATB, CATL, UPA, TPA and PAI-1 levels in DU and in control patients.

Samples of duodenal mucosa were obtained from 26 patients with active DU, from 26 patients with healed DU and from 21 controls. Antigen concentrations were measured using ELISA methods.

Significantly higher cathepsins, UPA, PAI-1 and significantly lower TPA were found in active DU than in healed DU and controls.

Our results demonstrate that, in DU patients, impaired fibrinolysis (TPA), activation of intramucosal proteases (cathepsins) and, with respect to healing, tissue remodelling and angiogenesis (UPA, PAI-1) may play an important role.

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Author information

Authors and Affiliations

  1. Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary

    L. Herszényi & Z. Tulassay

  2. Cattedra Malattie Apparato Digerente, Istituto di Medicina Interna, Italy

    F. Farinati, F. Di Mario, S. Kusstatscher & R. Naccarato

  3. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Universitá di Padova, Italy

    M. Plebani, P. Carraro & M. De Paoli

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  1. L. Herszényi
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  1. Pécs, Hungary

    Gy. Mózsik , L. Nagy  & A. Pár ,  & 

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    K. D. Rainsford

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Herszényi, L. et al. (1997). Cysteine and Serine Proteases in Duodenal Ulcer. In: Mózsik, G., Nagy, L., Pár, A., Rainsford, K.D. (eds) Cell Injury and Protection in the Gastrointestinal Tract. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5392-8_26

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  • DOI: https://doi.org/10.1007/978-94-011-5392-8_26

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