Abstract
A wide organoprotective action has already been described for the peptide BPC and its synthetic pentadecapeptide BPC 157, including gastroprotection in various ulcer models.
Ethanol-induced gastric lesions are one of the most-often used experimental models in gastroprotection analysis. In the present work, we analysed the morphological aspects of BPC 157 gastroprotection in ethanol-induced gastric damage by using: conventional microscopy, Monastral blue, scanning and transmission electron microscopy. In all experimental periods (1, 5, 60, 180 min and 24 h), we found significant differences between BPC 157-treated animals and controls. The most interesting elements were an apparent microvascular protection exerted by BPC 157 and a prominent mucus-like secretion covering the damaged surface, which appeared early and was more extensive in BPC-treated animals compared with controls.
We conclude that the gastroprotective effect of BPC could be a combination of vascular protection and production of a protective layer preventing further mucosal damage and possibly enhancing reepithelialization.
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© 1997 Springer Science+Business Media Dordrecht
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Seiwerth, S. et al. (1997). Morphological Aspects of BPC-Peptide Protection in Ethanol-Induced Gastric Lesions in Rats. In: Mózsik, G., Nagy, L., Pár, A., Rainsford, K.D. (eds) Cell Injury and Protection in the Gastrointestinal Tract. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5392-8_11
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DOI: https://doi.org/10.1007/978-94-011-5392-8_11
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