The Heat Shock Response and Tissue Protection

  • R. W. Currie
  • J.-C. L. Plumier
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 207)


The name of heat shock proteins (HSPs) comes from their initial discovery following heat shock treatment. In the early 1960s, Ferruccio Ritossa made the first observation that elevated temperature could trigger rapid and specific changes in chromosomal and metabolic activity of living organisms; new mRNA was synthesised within 2–3 minutes [1, 2]. During the 1970s several laboratories discovered that novel (heat shock) proteins were expressed in cells after brief elevation of temperature [3–5]. At about the same time it was also recognised that these changes in gene expression, induced by mild heat shock, were associated with a subsequent tolerance of cells [6] and organisms [7] to severe thermal injury. These pioneering studies in Drosophila cells [1–7] lead to discoveries of HSPs in all cells from bacteria to man [8], and of inducible and transient cellular protection in cells and organs as varied as heart, brain, kidney and retina, the subject of this chapter.


Heat Shock Heat Shock Protein Infarct Size Heat Shock Response Heat Shock Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • R. W. Currie
  • J.-C. L. Plumier

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