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Computer Simulations for Microchip Electrophoresis

  • Conference paper
Micro Total Analysis Systems ’98

Abstract

A mathematical model describing electrokinetically driven mass transport phenomena in microfabricated chip devices is presented. The model accounts for principal material transport mechanisms including electrokinetic migration (electrophoresis and electroosmosis) and diffusion. A computer code that implements the model is capable of simulating the mass transport during electrokinetic manipulation in any 2-D channel structures. The code allows arbitrary channel geometries with various boundary conditions for the electric field and the sample concentration. The results simulating the sample mass transport in a cross channel geometry during different types of electrokinetic injection are presented.

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References

  1. Harrison, D.J.; Manz, A.; Fan, Z.; Lüdi, H.; Widmer, H.M. Anal. Chem., 1992, 64, 1926.

    Article  Google Scholar 

  2. Effenhauser, C.S.; Manz, A.; Widmer, H.M. Anal. Chem. 1993, 65, 2637.

    Article  Google Scholar 

  3. Jacobson, S.C.; Hergenröder, R.; Koutny, L.B.; Warmack, R.J.; Ramsey, J.M. Anal. Chem., 1994, 66, 1107.

    Article  Google Scholar 

  4. Colyer, C. L.; Mangru, S. D.; Harrison, D. J J. Chromatogr., 1997, 781, 271.

    Article  Google Scholar 

  5. Woolley, A.T.; Mathies, R.A. Anal. Chem. 1995, 67, 3676.

    Article  Google Scholar 

  6. Jacobson, S.C.; Hergenröder, R.; Koutny, A.W.; Ramsey, J.M. Anal. Chem. 1994, 66, 4127.

    Article  Google Scholar 

  7. Kutter, J.P.; Jacobson, S.C.; Ramsey, J.M. Anal. Chem. 1997, 69, 5165.

    Article  Google Scholar 

  8. Jacobson, S.C.; Hergenröder, R.; Moore, L.B.; Warmack, R.J.; Ramsey, J.M. Anal. Chem., 1994, 66, 1107.

    Article  Google Scholar 

  9. Babskii, V.G.; Zhukov, M.Yu.; Yudovich, V.I. Mathematical Theory of Electrophoresis; Consultants Bureau: New York, 1989.

    Google Scholar 

  10. Mosher, R.A.; Saville, D.A.; Thormann, W. The Dynamics of Electrophoresis, VCH: Weinheim, 1992.

    Google Scholar 

  11. Patankar, N.A., Hu, H.H. Anal. Chem., 1998, 70, 1870.

    Article  Google Scholar 

  12. Jacobson, S.C.; Culbertson C.T.; Ramsey, J.M. Anal. Chem. 1998, in press.

    Google Scholar 

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© 1998 Springer Science+Business Media Dordrecht

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Ermakov, S.V., Jacobson, S.C., Ramsey, J.M. (1998). Computer Simulations for Microchip Electrophoresis. In: Harrison, D.J., van den Berg, A. (eds) Micro Total Analysis Systems ’98. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5286-0_36

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  • DOI: https://doi.org/10.1007/978-94-011-5286-0_36

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6225-1

  • Online ISBN: 978-94-011-5286-0

  • eBook Packages: Springer Book Archive

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