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System Requirements for a Portable Cell Based Sensor

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Micro Total Analysis Systems ’98

Abstract

The use of cell based biosensors outside of the laboratory has been limited due to many issues including preparation of the sample, maintenance of the biological environment, incorporation of the appropriate sensors, and integration of the electronics for data collection and analysis. This paper describes these system issues and briefly presents current efforts to address packaging, fluidics, and data interpretation. These include the development of an integrated silicon-PDMS cell cartridge system that provides reliable electrical and fluidic interconnect and a regulated cell environment, the development of low power and low overhead sensors and electronics, and the necessary fluidic sample preparation.

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References

  1. L. Bousse, “Whole Cell Biosensors,” Sensors and Actuators B (Chemical), B34(l-3) (1996) 270–5.

    Article  Google Scholar 

  2. G. W. Gross, B. K. Rhoades, H. M. E. Azzazy, and M. Wu, “The Use of Neuronal Networks on Multielec-trode Arrays as Biosensors,” Biosensors & Bioelectronics, 10(6–7) (1995) 553–67.

    Article  Google Scholar 

  3. C. R. Keese and I. Giaever, “A Biosensor that Monitors Cell Morphology with Electric Fields,” IEEE Engineering in Medicine and Biology, 13(3) (June/July 1994) 402–8.

    Article  Google Scholar 

  4. H. M. McConnell, J. C. Owicki, J. W. Parce, D. L. Miller, G. T. Baxter, H. G. Wada, and S. Pitchford, “The Cytosensor Microphysiometer: Biological Applications of Silicon Technology,” Science, 257 (25 September 1992) 1906–12.

    Article  Google Scholar 

  5. D. A. Borkholder, B. D. DeBusschere, and G. T. A. Kovacs, “An Approach to the Classification of Unknown Biological Agents With Cell Based Sensors,” Technical digest of the 1998 Solid-State Sensor and Actuator Workshop, Hilton Head Island, SC, 6/7–6/11, Transducer Research Foundation, Cleveland (1998) 178–82.

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  6. B. D. DeBusschere, D. A. Borkholder, and G. T. A. Kovacs, “Design of an Integrated Silicon-PDMS Cell Cartridge,” Technical digest of the 1998 Solid-State Sensor and Actuator Workshop, Hilton Head Island, SC, 6/7–6/11, Transducer Research Foundation, Cleveland (1998) 358–62.

    Google Scholar 

  7. R. Eckert and D. Randall, Animal Physiology, W.H. Freeman and Co., San Francisco, CA, 1978.

    Google Scholar 

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© 1998 Springer Science+Business Media Dordrecht

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DeBusschere, B.D., Borkholder, D.A., Kovacs, G.T.A. (1998). System Requirements for a Portable Cell Based Sensor. In: Harrison, D.J., van den Berg, A. (eds) Micro Total Analysis Systems ’98. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5286-0_106

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  • DOI: https://doi.org/10.1007/978-94-011-5286-0_106

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6225-1

  • Online ISBN: 978-94-011-5286-0

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