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Pain Management and Anesthesiology pp 217–236Cite as

Spinal Opioids: Clinical Applications for Acute and Chronic Pain

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Part of the book series: Developments in Critical Care Medicine and Anesthesiology ((DCCA,volume 33))

Abstract

Spinal delivery of analgesic agents is widely utilized in clinical practice, and the concept of “selective spinal analgesia” is well accepted. The safety and efficacy of spinal opioid analgesia has been established, although questions appropriately arise concerning selection of this technique versus systemic medication (1). Significant advances have been made in opioid pharmacology (including understanding of the “plasticity” of opioid mechanisms, and the recent discovery of new endogenous opioid peptides), and the pharmacology of the primary afferent synapse in the dorsal horn (with identification of multiple receptor mechanisms which can modulate pain transmission).

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  1. S. M. Walker
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  2. M. J. Cousins
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  3. D. B. Carr
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Editors and Affiliations

  1. Department of Anesthesiology, The University of Utah Medical School, Salt Lake City, Utah, USA

    Michael A. Ashburn , Perry G. Fine  & Theodore H. Stanley ,  & 

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Walker, S.M., Cousins, M.J., Carr, D.B. (1998). Spinal Opioids: Clinical Applications for Acute and Chronic Pain. In: Ashburn, M.A., Fine, P.G., Stanley, T.H. (eds) Pain Management and Anesthesiology. Developments in Critical Care Medicine and Anesthesiology, vol 33. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5145-0_19

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