Effects of hypoxia and hypercapnia on cardiac contractility and energetics
The main goal of the regulation of lung ventilation is to maintain blood concentrations of oxygen and carbon dioxide at physiological levels.1Here we will consider effects of hypoxia and hypercapnia on the heart, the pump which takes care of the transport of oxygen and carbon dioxide between the lung and the rest of the body. Oxygen supply to the heart tissue is essential to provide energy for the cardiac pump function. Depression of cardiac aerobic metabolism is dangerous, because the heart provides the driving force for its own perfusion and oxygen supply. A surplus of carbon dioxide in the blood, hypercapnia, leads to a fast increase in acidity in the heart muscle cell, suppressing cardiac contractility. Adequate control of lung ventilation is therefore important to the heart, but we will see that the heart itself can cope with hypoxemia and hypercapnia within certain limits.
KeywordsCardiac Contractility Arterial Oxygen Saturation Myocardial Stunning Develop Left Ventricular Pressure Heart Muscle Cell
Unable to display preview. Download preview PDF.
- 1.Berkenbosch A. Chemical Control of Breathing. Thesis, Rijksuniversiteit Leiden, 1987.Google Scholar
- 2.Van den Aardweg JG. Cardiovascular Effects of Cyclic Changes in Breathing Pattern. Thesis, Universiteit van Amsterdam, 1992.Google Scholar
- 13.Van Beek JHGM, Tian X, Zuurbier CJ, de Groot B, van Echteid CJA, Eijgelshoven MHJ, Hak JB. The dynamic regulation of myocardial oxidative phosphorylation. Analysis of the response time of oxygen consumption (Review). Moll Cell Biochem, in press.Google Scholar
- 16.Van Wijhe MH, Van Beek JHGM. Effects of respiratory and metabolic acidosis on oxidative phosphorylation in isolated rabbit heart mitochondria. Pflügers Arch. (Eur J Physiol) 430: R174, 1995.Google Scholar