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Multiple Risk Factors in Cardiovascular Disease pp 1–7Cite as

New Insights into the Role of HDL in the Development of Cardiovascular Disease

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Part of the book series: Medical Science Symposia Series ((MSSS,volume 12))

Abstract

Epidemiological studies have consistently demonstrated that plasma concentrations of high density lipoprotein (HDL) cholesterol are inversely correlated with the incidence of coronary heart disease (CHD) [1,2]. Although the mechanisms by which HDL protects against atherosclerosis remain to be definitively established, HDL has been postulated to facilitate the efflux of cholesterol from peripheral cells and transport the cholesterol back to the liver in a process termed reverse cholesterol transport [3]. The major apolipoprotein constituents of HDL are apoA-I and apoA-II. Plasma concentrations of apoA-I are inversely correlated with CHD, however the association of apoA-II levels with CHD has not been consistent [4,5]. A schematic overview of the proposed role of HDL in reverse cholesterol and lipoprotein metabolism is illustrated in Figure 1.

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Authors
  1. H. Bryan Brewer Jr.
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Editor information

Editors and Affiliations

  1. Cornell University Medical College, 1300 York Avenue, Room F-105, New York, NY, USA

    Antonio M. Gotto Jr.

  2. National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

    C. Lenfant

  3. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Rodolfo Paoletti  & A. L. Catapano  & 

  4. Giovanni Lorenzini Medical Foundation, Houston, TX, USA

    A. S. Jackson

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© 1998 Springer Science+Business Media Dordrecht

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Brewer, H.B. (1998). New Insights into the Role of HDL in the Development of Cardiovascular Disease. In: Gotto, A.M., Lenfant, C., Paoletti, R., Catapano, A.L., Jackson, A.S. (eds) Multiple Risk Factors in Cardiovascular Disease. Medical Science Symposia Series, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5022-4_1

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  • DOI: https://doi.org/10.1007/978-94-011-5022-4_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6108-7

  • Online ISBN: 978-94-011-5022-4

  • eBook Packages: Springer Book Archive

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