The role of T-cell costimulatory pathways in ischemia—reperfusion injury
Prolonged cold ischemia time prior to engraftment of donor organs has been shown to lead to an increased incidence of delayed graft function and decreased survival of renal allografts [1, 2]. The reasons for this are incompletely understood, but it has been postulated that exposure to ischemia-reperfusion injury increases the ‘immunogenecity’ of the graft and makes ‘it’ more rejectable . Although studies have shed some light on individual factors which contribute to the effects of this type of injury, an overall understanding of how a ‘nonantigen-dependent’ factor such as ischemia-reperfusion injury influences an immune response is still not totally clear.
KeywordsChronic Rejection Urinary Protein Excretion Delay Graft Function Costimulatory Pathway Costimulatory Blockade
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