Advertisement

The role of T-cell costimulatory pathways in ischemia—reperfusion injury

  • A. Chandraker
  • M. H. Sayegh
Part of the Transplantation and Clinical Immunology book series (TRAC, volume 30)

Abstract

Prolonged cold ischemia time prior to engraftment of donor organs has been shown to lead to an increased incidence of delayed graft function and decreased survival of renal allografts [1, 2]. The reasons for this are incompletely understood, but it has been postulated that exposure to ischemia-reperfusion injury increases the ‘immunogenecity’ of the graft and makes ‘it’ more rejectable [3]. Although studies have shed some light on individual factors which contribute to the effects of this type of injury, an overall understanding of how a ‘nonantigen-dependent’ factor such as ischemia-reperfusion injury influences an immune response is still not totally clear.

Keywords

Chronic Rejection Urinary Protein Excretion Delay Graft Function Costimulatory Pathway Costimulatory Blockade 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Halloran P, Aprile M. Factors influencing early renal function in cadaver kidney transplants. A case-control study. Transplantation. 1988; 45: 122–127.Google Scholar
  2. 2.
    Troppmann C, Gillingham KJ, Benedetti E et al. Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. A multivariate analysis. Transplantation. 1995; 59: 962–968.Google Scholar
  3. 3.
    Shoskes DA, Parfrey NA, Halloran PF. Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse. Transplantation. 1990; 49: 201–207.PubMedCrossRefGoogle Scholar
  4. 4.
    Kelly KJ, Bonventre JV. Ischemia/reperfusion injury in transplantation. In: Tilney NL, Strom TB, Paul LC (eds.), Transplantation Biology: Cellular and Molecular Aspects. Philadelphia: Lippincott-Raven; 1996: 257–274.Google Scholar
  5. 5.
    Land W, Messmer K. The impact of ischemia/reperfusion injury on specific and non-specific early and late chronic events after organ transplantation. Transplant. Rev. 1996; 10: 108–127.CrossRefGoogle Scholar
  6. 6.
    Land W, Schneeberger H, Schleibner S et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation. 1994; 57: 211–217.PubMedCrossRefGoogle Scholar
  7. 7.
    Paul LC, Tilney NL. Alloantigen-dependent events in chronic rejection. In: Tilney NL, Strom TB, Paul LC (eds.), Transplantation Biology: Cellular and Molecular Aspects. Philadelphia: Lippincott-Raven; 1996: 567–575.Google Scholar
  8. 8.
    Grinyo JM, Gil-Vernet S, Moreso F et al. Ischemia-reperfusion injury as a risk factor for late kidney graft failure. In: Touraine JL et al. (eds.), Late Graft Loss. Dordrecht: Kluwer; 1997: 77–83.CrossRefGoogle Scholar
  9. 9.
    Goes N, Urmson J, Ramassar V, Halloran PF. Ischemic acute tubular necrosis induces an extensive local cytokine response. Evidence for induction of interferon-gamma, transforming growth factor-beta 1, granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-10. Transplantation. 1995; 59: 565–572.PubMedGoogle Scholar
  10. 10.
    Wanders A, Akyurek ML, Waltenberger J et al. Ischemia-induced transplant arteriosclerosis in the rat. Arterioscler. Thromb. Vasc. Biol. 1995; 15: 145–155.PubMedGoogle Scholar
  11. 11.
    Takada M, Nadeau KC, Shaw GD, Marquette KA, Tilney NL. The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney inhibition by a soluble P-selectin ligand. J. Clin. Invest. 1997; 99: 2682–2690.PubMedCrossRefGoogle Scholar
  12. 12.
    Sayegh MH, Turka LA. T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction. J. Am. Soc. Nephrol. 1995; 6: 1143–1150.PubMedGoogle Scholar
  13. 13.
    Takada M, Chandraker A, Nadeau KC, Sayegh MH, Tilney NL. The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury. J. Clin. Invest. 1997; 100: 1199–1203.PubMedCrossRefGoogle Scholar
  14. 14.
    Chandraker A, Takada M, Nadeau KC, Peach R, Tilney NL, Sayegh MH. CD28–B7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury. Kidney Int. 1997; 52: 1678–1684.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • A. Chandraker
  • M. H. Sayegh

There are no affiliations available

Personalised recommendations