The problem of infectious transmission from donors in organ transplantation

  • A. Pahissa
Part of the Transplantation and Clinical Immunology book series (TRAC, volume 30)


The number of organs transplanted increases each year, creating the need for increased organ procurement, especially from cadaveric donors. Guidelines on donor selection have been designed to exclude donors with evidence of infectious diseases, or who have diseases of unknown origin that could prove infectious. Concerns arise from reports of infections transmitted from the donor to the recipient of an allograft. As a result, screening potential donors for infections is routine, as is taking blood or allograft cultures from cadaveric donors at the time of organ harvesting.


Cystic Fibrosis Transplant Recipient Mycobacterium Tuberculosis Lung Transplant Bacterial Meningitis 
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  1. 1.
    Häyry P, Renkonen O-V. Frequency and fate of human renal allografts contaminated prior to transplantation. Surgery. 1979; 85: 404–407.PubMedGoogle Scholar
  2. 2.
    McCoy GC, Loening S, Braun WE, Magnusson MO, Banowsky JH, McHenry MC. The fate of cadaver renal allografts contaminated before transplantation. Transplantation. 1975; 20: 467–472.PubMedCrossRefGoogle Scholar
  3. 3.
    Spees EK, Light JA, Oakes DD, Reinmuth B. Experiences with cadaver renal allograft contamination before transplantation. Br. J. Surg. 1982; 69: 482–485.PubMedCrossRefGoogle Scholar
  4. 4.
    Anderson Ch, Haid S, Hruska K, Etheredge E. Significance of microbial contamination of stored cadaver kidneys. Arch. Surg. 1978; 113: 269–271.PubMedCrossRefGoogle Scholar
  5. 5.
    Majeski J, Alexander J, First M, Munda R, Fidler J, Craycraft T. Transplantation of microbially contaminated cadaver kidneys. Arch. Surg. 1982; 117: 221–224.PubMedCrossRefGoogle Scholar
  6. 6.
    Lopez-Navidad A, Domingo P, Caballero F, Gonzalez C, Santiago C. Successful transplantation of organs retrieved from donors with bacterial meningitis. Transplantation. 1997; 64: 365–368.PubMedCrossRefGoogle Scholar
  7. 7.
    Bull DA, Stahl RD, McMahan DL et al. The high-risk heart donor: potential pitfalls. J. Heart Lung Transplant. 1995; 14: 424–428.PubMedGoogle Scholar
  8. 8.
    Gonzalez-Ruiz A, Pérez G, Lumbreras C et al. Importance of unrecognized donor bacteremia in determining the early outcome of solid organ transplant recipients. Communication J-101, ICAAC 1997, Toronto.Google Scholar
  9. 9.
    Miller RA, Lanza LA, Kline JN, Geist LJ. Mycobacterium tuberculosis in lung transplant recipients. Am. J. Respir. Crit. Care Med. 1995; 152: 374–376.PubMedGoogle Scholar
  10. 10.
    Steinbach S, Sun L, Jiang RZ et al. Transmissibility of Pseudomonas cepacia infection in clinic patients and lung-transplant recipients with cystic fibrosis. N. Engl. J. Med. 1994; 331: 981–987.PubMedCrossRefGoogle Scholar
  11. 11.
    Ridgeway A, Warner G, Phillips P et al. Transmission of Mycobacterium tuberculosis to recipients of single lung transplants from the same donor. Am. J. Respir. Crit. Care Med. 1996; 153: 1166–1168.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1998

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  • A. Pahissa

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