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Acid-adaptive mechanisms of gastric Helicobacter

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Helicobacter pylori

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Abstract

Helicobacter pylori survive over a pH range from 4.0 to 8.0 in buffer if they are not acid-adapted and between 3.5 and 8.0 after acid adaptation1,2. They grow over a pH range from 6.0 to 8.0. These properties, as shown in Figure 1, define these organisms as neutralophiles. It is of interest to note that the pH over which growth occurs is narrower than the pH range of survival. If the pH in the stomach were able to allow the organisms to survive but not to grow, then these surviving organisms would be relatively insensitive to growth dependent antibiotics such as clarithromycin and the penicillins. The fraction that is dividing would be affected given gastric access and adequate gastric dwell time of the antibiotic. This distribution of the organisms between stationary and log phase may account for the relative failure of dual-antibiotic therapy as a regimen for eradication of this gastric pathogen3.

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Authors
  1. D. Scott
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  2. D. Weeks
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  3. M. Rektorschek
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  4. G. Sachs
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  5. K. Melchers
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1998 Springer Science+Business Media Dordrecht

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Scott, D., Weeks, D., Rektorschek, M., Sachs, G., Melchers, K. (1998). Acid-adaptive mechanisms of gastric Helicobacter . In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4882-5_16

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  • DOI: https://doi.org/10.1007/978-94-011-4882-5_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6046-2

  • Online ISBN: 978-94-011-4882-5

  • eBook Packages: Springer Book Archive

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