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Molecular mechanisms of leukotriene synthesis: the changing paradigm

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Leukotrienes

Abstract

Leukotrienes (LTs) are potent lipid mediators which modulate a multitude of fundamental intracellular processes. While their pathophysiological role has been best established in asthma, they are probably important participants in many other disease processes characterized by inflammation, cellular proliferation, and fibrogenesis. They also subserve a homoeostatic role in antimicrobial host defence1. In view of the actions and importance of LTs, substantial effort over the last several years has been directed at increasing our understanding of their synthesis. The purpose of this brief chapter will be to review these recent advances in LT synthesis, with an emphasis on the biochemistry, molecular biology and cell biology of the key enzymes involved.

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Authors
  1. M. Peters-Golden
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Editor information

Editors and Affiliations

  1. Merck Frosst Canada, Inc., Pointe-Claire-Dorval, Quebec, Canada

    Ian Rodger

  2. The William Harvey Research Institute, Saint Bartholomew’s Hospital Medical College, London, UK

    Jack Botting

  3. Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Sven-Erik Dahlén

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© 1998 Springer Science+Business Media Dordrecht

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Peters-Golden, M. (1998). Molecular mechanisms of leukotriene synthesis: the changing paradigm. In: Rodger, I., Botting, J., Dahlén, SE. (eds) Leukotrienes. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4880-1_1

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  • DOI: https://doi.org/10.1007/978-94-011-4880-1_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6045-5

  • Online ISBN: 978-94-011-4880-1

  • eBook Packages: Springer Book Archive

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