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Inhibition of intestinal tumorigenesis via selective inhibition of COX-2

  • R. N. Dubois
  • H. Sheng
  • J. Shao
  • C. Williams
  • R. D. Beauchamp

Abstract

Clinical studies have shown a 40–50% reduction in relative risk of colorectal cancer in individuals taking aspirin on a regular basis 1–6. Persons with familial adenomatous polyposis (FAP) who take sulindac show a striking reduction in adenoma size and number7–11. Since a potential target of these drugs is the cyclooxygenase (COX) enzymes, we set out to determine if COX-1 or -2 was dysregulated during the malignant transformation of intestinal epithelial cells.

Keywords

Familial Adenomatous Polyposis Colorectal Tumorigenesis Transform Growth Factor Beta Receptor Intestinal Tumorigenesis Sulindac Sulfide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • R. N. Dubois
  • H. Sheng
  • J. Shao
  • C. Williams
  • R. D. Beauchamp

There are no affiliations available

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