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COX-2 in brain and retina: role in neuronal survival

  • N. G. Bazan
  • V. L. Marcheselli
  • P. K. Mukherjee
  • W. J. Lukiw
  • W. C. Gordon
  • D. Zhang

Abstract

Various forms of injury to the central nervous system, such as in neurodegenerative diseases, sets in motion an inflammatory-like response. The messengers that accumulate are normal modulators of functions; however, above certain concentrations they trigger neuronal damage. The significance of these early warning events has recently been highlighted by the observation that patients receiving chronic treatments with certain anti-inflammatory drugs develop less severe symptoms of Alzheimer’s Disease. Cyclooxygenase-2 (COX-2) and platelet-activating factor (PAF), mediators of the inflammatory response, may thus play a role in Alzheimer’s Disease and in other neurodegenerative diseases.

Keywords

Glutamate Release Kainic Acid Bioactive Lipid Kainic Acid Injection Lipid Messenger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • N. G. Bazan
  • V. L. Marcheselli
  • P. K. Mukherjee
  • W. J. Lukiw
  • W. C. Gordon
  • D. Zhang

There are no affiliations available

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