COX-2 in brain and retina: role in neuronal survival

  • N. G. Bazan
  • V. L. Marcheselli
  • P. K. Mukherjee
  • W. J. Lukiw
  • W. C. Gordon
  • D. Zhang


Various forms of injury to the central nervous system, such as in neurodegenerative diseases, sets in motion an inflammatory-like response. The messengers that accumulate are normal modulators of functions; however, above certain concentrations they trigger neuronal damage. The significance of these early warning events has recently been highlighted by the observation that patients receiving chronic treatments with certain anti-inflammatory drugs develop less severe symptoms of Alzheimer’s Disease. Cyclooxygenase-2 (COX-2) and platelet-activating factor (PAF), mediators of the inflammatory response, may thus play a role in Alzheimer’s Disease and in other neurodegenerative diseases.


Glutamate Release Kainic Acid Bioactive Lipid Kainic Acid Injection Lipid Messenger 
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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • N. G. Bazan
  • V. L. Marcheselli
  • P. K. Mukherjee
  • W. J. Lukiw
  • W. C. Gordon
  • D. Zhang

There are no affiliations available

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