Abstract
Background. The Western community is currently increasingly involved in the problems of patients with chronic diseases. The wish to deal with such problems gives rise to new endpoints in medical research.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wilson JB, Cleary PD. Linking clinical variables with health-related qualify of life. JAMA 1995; 273: 59–65.
Gill TM, Feinstein AR. A critical appraisal of the quality of life measurements. JAMA 1994; 272: 619–626.
Cleophas TJ, de Jong SJ, Niemeyer MG, Tavenier P, Zwinderman K, Kuyper A. Changes in life-style in men under sixty years of age before and after acute myocardial infarction: a case-control study. Angiology 1993; 44: 761–768.
Shaw GB. Mrs. Warren’s profession. Oxford, UK, University Press, 1925.
Anonymous. The inhumanity and humanity of medicine. Dying for palliative care. Br Med J 1994; 309: 1696–1699.
Cleophas TJ. The use of placebo controls. N Engl J Med 1995; 332: 61.
Cleophas TJ. The importance of placebo effects. JAMA 1995; 273: 283–284.
Griffith PL. The 5 minute consult. Philadelphia: Lea & Febinger, 1994.
Moses LE. Statistical concepts fundamental to investigations. N Engl J Med 1985; 312: 890–897.
Cleophas TJ. Clinical trials in chronic diseases. J Clin Pharmacol 1995; 35: 594–598.
Cornfield J, O’Neill RT Minutes of the Food and Drug Administration Advisory Committee Meeting, June, 23, 1976.
Wallenstein S, Fisher AC. The analysis of the two-period repeated measurements crossover design with application to clinical trials. Biometrics 1977; 33: 261–269.
Zimmermann H, Rahlfs V. Testing hypotheses in the two-period change-over with binary data. Biom J 1978; 20: 133–141.
Hills M, Armitage P. The two-period crossover clinical trial. Br J Clin Pharmacol 1979; 8: 7–20.
Brown BW. The crossover experiment for clinical trials. Biometrics 1980; 36: 69–79.
Presscott RJ. The comparison of success rates in crossover trials in the presence of an order effect. Appl Stat 1981; 30: 9–15.
Barker M, Hew RJ, Huitson A, Poloniecki J. The two-period crossover trial. Bull Appl Stat 1982; 9: 67–112.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Cleophas, T.J. (1999). Clinical Trials: New Endpoints. In: Human Experimentation. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4663-0_8
Download citation
DOI: https://doi.org/10.1007/978-94-011-4663-0_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-5827-5
Online ISBN: 978-94-011-4663-0
eBook Packages: Springer Book Archive