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Transdermal Systems with Poly-2-Hydroxyethylmeth-Acrylates and new Biological Models for their Study

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NBC Risks Current Capabilities and Future Perspectives for Protection

Part of the book series: NATO Science Series ((ASDT,volume 25))

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Abstract

Skin may be one of the important entrance routes to the human organism. However the skin barrier alone is not able properly regulate the flux of penetrating active substances. The flux of drugs from containment systems (patch, or transdermal terapeutic systems) can be controlled by the construction/composition of their membranes or matrices or by both these regulators. This mode enables us to reach with advantage either a very high local level of drugs in body tissues or relatively constant and smooth levels of xenobiotics in blood during hours and even days, also in the case of drugs with short biologic half-life and drugs with pronounced first-pass effect.

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Author information

Authors and Affiliations

  1. Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovak Republic

    V. Koprda

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  1. V. Koprda
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Editor information

Editors and Affiliations

  1. Department of Studies and Science, German Armed Forces Medical Academy, Munich, Germany

    Torsten Sohns  & Harald Kempf  & 

  2. University of Medicine & Pharmacy ”Carol Davila”, Bucharest, Romania

    Victor A. Voicu

  3. Department of Studies and Science, Institute of Pharmacology and Toxicology, German Armed Forces Medical Academy, Munich, Germany

    Ladislaus Szinicz

  4. Department of Studies and Science, Institute of Microbiology, German Armed Forces Medical Academy, Munich, Germany

    Ernst-Juergen Finke

  5. Army Center of Medical Research and University of Medicine and Pharmacy „Carol Davila“, Bucharest, Romania

    Constantin Mircioiu

  6. Defence Research Establishment Suffield, Box 4000, Medicine Hat, Alberta, TIB 2 P5, Canada

    P. Lundy

  7. An-Ex, Redwood Building, Cf 1 3xF, Cardiff, UK

    Keith R. Brain

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© 1999 Springer Science+Business Media Dordrecht

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Koprda, V. (1999). Transdermal Systems with Poly-2-Hydroxyethylmeth-Acrylates and new Biological Models for their Study. In: Sohns, T., et al. NBC Risks Current Capabilities and Future Perspectives for Protection. NATO Science Series, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4641-8_28

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  • DOI: https://doi.org/10.1007/978-94-011-4641-8_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-5803-9

  • Online ISBN: 978-94-011-4641-8

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