Abstract
Cell death in organisms can be caused by two distinct mechanism: apoptosis and necrosis. These two processes were studied in human leukemic cell lines HL-60 and U-937 after exposure to y-radiation (6 Gy) and C2-ceramide (µM). Apoptosis was induced by C2-ceramide treatment in both cell lines, whereas after y-irradiation it was detected only in U-937 cells, wheras HL-60 cells died by necrosis. The different behaviour of U-937 and HL-60 cells is apparently caused by differences in expression of some protooncogenes in the two cell lines. Two different apoptotic pathways may exist: one, observed only after the exposure to C2-ceramide, is ceramide-induced apoptosis and the other, observed after y-radiation treatment, is p53-dependent.
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© 1999 Springer Science+Business Media Dordrecht
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Bártová, E., Španová, A. (1999). Differences in the Induction of Apoptosis After Treatment with γ-Irradiation and C2-Ceramide. In: Baumstark-Khan, C., Kozubek, S., Horneck, G. (eds) Fundamentals for the Assessment of Risks from Environmental Radiation. NATO Science Series, vol 55. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4585-5_38
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DOI: https://doi.org/10.1007/978-94-011-4585-5_38
Publisher Name: Springer, Dordrecht
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