Abstract
It is known that the interaction of the biologically active ligands with DNA molecules extracted from usual and transformational tissue depends on the degradation level of the chromatine [1, 2]. In our recent investigation was shown that anticancer drug cytosine arabinoside binds with the control and radiation-induced DNA molecules in different ways [3]. The aim of the present study was the comparison of the binding of the three pyrimidine nucleosides (NUC) — cytosine arabinoside (Ara-C), 6-azacytidine (6-AZC), 6-azauridine (6-AZU) — with DNA molecules extracted from the sex cells of the rats irradiated at low doses.
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© 1999 Springer Science+Business Media Dordrecht
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Kruglova, E., Krutko, N., Krasnitskaya, A., Alesina, M., Karpenko, N. (1999). Therapeutically important nucleosides as markers of the level of DNA damages induced in sex cells of the rats by low doses gamma-radiation. In: Greve, J., Puppels, G.J., Otto, C. (eds) Spectroscopy of Biological Molecules: New Directions. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4479-7_135
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DOI: https://doi.org/10.1007/978-94-011-4479-7_135
Publisher Name: Springer, Dordrecht
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