Abstract
Next to heavy metals and pesticides in drinking water, pharmaceuticals are of new concern in water research in Germany. Pharmaceuticals are in many aspects similar to water. Because of this, their separation from the water matrix, as well as the analysis, is quite challenging. Many compounds are stable for weeks, but are frequently degraded to stable metabolites, which need also be investigated, as well as the original substance. Drugs are mostly polar substances and difficult to break down. They pass through the wastewater treatment plant and hence enter the receiving surface waters. If drinking water is produced through a bank filtration, as is often the case in Germany, these drugs can also be found in it in low concentrations. An unanswered question is still whether these polar substances, occurring in surface water often in concentrations higher than 1 μg/l, are harmful to the ecosystem and man. In any case, they should not occur in drinking water.
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References
Forth, W., Henschler, D., Rummel, W., and Starke, K. (1992), Allgemeine und spezielle Pharmakologie und Toxikologie, Wissenschaftsverlag Manheim/Leipzig/Wien/Zürich. 6. Auflage 1992.
Garrison, A.W., Pope, J.D., and Allen, F.R. (1976), GC/MS analysis of organic compounds in domestic wastewaters. In: identification and analysis of organic pollutants in water, Identification and Analysis of Organic Pollutants in Water. C.H. Keith ed., Ann Arbor Science Publishers Inc. 517–566.
Haberer, K. und Ternes, Th. A. (1996), Bedeutung von wasserwerksgängigen Metaboliten für die Trinkwasserversorgung. GWF-Zeitschrift far Wasser und Abwasserforschung 10, 573–578.
Heberer, Th. and Stan, H.-J. (1996), Vorkommen von polaren organischen Kontaminanten im Berliner Trinkwasser. Vom Wasser 86, 19–31.
Heberer, Th. and Stan, H.-J. (1997a), Determination of clofibric acid and N(phenylsulfonyl)-sarcosine in sewage, river and drinking water, Int. J. Environ. Anal. Chem 67, 113–24.
Heberer, Th., Dünnbier, U., Reilich, Ch., and Stan, H.J. (1997b), Detection of drugs and drug metabolites in ground water samples of a drinking water treatment plant, Fresenius’ Environ. Bull. 6, 438–443.
Hignite Ch. and Azamoff D.L. (1977), Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sciences 20, 337–342.
Hirsch, R., Temes, Th. A., Haberer, K., und Kratz, K.-L. (1996), Vorkommen von Betablocker und Bronchospasmolytika in Kläranlagen und Fließgewässern, Vom Wasser 87, 263–274.
Hirsch, R., Ternes, Th. A., Mehlig, A., Ballwanz, F., Kratz, K.L., and Haberer, K. (1998a), Multi method for the determination of anitbiotics in aqueous martices using LC/MS/MS. J. Chromatogr. in press.
Hirsch, R, Ternes, Th. A., Kratz, K. L., and Haberer, K. (1998b), Occurrence of antibiotics in the aquatic environment, Sci. Total Environ, in preparation.
Rote, L. (1994), Arzneimittelverzeichnis des BPI, hrsg.: Bundesverband der pharmazeutischen Industrie e.V., EV Editor Cantor Verlag für Medizin und Naturwissenschaften GmbH
Schwabe, U. and Paffrath, D. (1994), Arzneiverordnungsreport ‘84. Aktuelle Daten, Kosten, Trends und Kommentare, Gustav Fischer Verlag, Stuttgart/Jena.
Stan, H.-J. and Linkerhägner, M. (1992), Identifizierung von 2-(4- Chlorphenoxy)-2-methyl-propionsäure im Grundwasser mittels kapillarGaschromatographie mit Atomemissionsdetektion und Massenspektrometrie. Vom Wasser 79, 75–88.
Stan, H.-J., Heberer, Th., and Linkerhägner, M. (1994), Vorkommen von Clofibrinsäure im aquatischen System - Führt die therapeutische Anwendung zu einer Belastung von Oberflächen-, Grund-und Trinkwasser? Vom Wasser 83, 57–68
Stumpf, M., Temes, Th. A., Haberer, K., und Baumann, W. (1996a), Nachweis von syntetischen und natürlichen Östrogenen in Kläranlagen und Fließgewässern, Vom Wasser 87, 251–261.
Stumpf, M., Temes, Th.A., Haberer, K., Seel, P. and Baumann, W. (1996b), Nachweis von Arzneimittelrückständen in Kläranlagen und Fließgewässern, Vom Wasser 86, 291–303.
Ternes, Th. A., Stumpf, M., Schuppert, B., and Haberer, K. (1998), Determination of acidic drugs and antiseptics in sewage and river water, Vom Wasser 90, 295–309.
Temes, Th. A. (1998a), Occurrence of drugs in German sewage treatment plants and rivers. Water Research, in press.
Temes, Th. A., Hirsch, R., Müller, J., and Haberer, K. (1998b), Method for the determination of neutral drugs as well as β2-sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS, Fresenius J. Anal. Chem, in press.
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© 2000 Springer Science+Business Media Dordrecht
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Wilken, RD., Ternes, T.A., Heberer, T. (2000). Pharmaceuticals in Sewage, Surface and Drinking Water in Germany. In: Deininger, R.A., Literathy, P., Bartram, J. (eds) Security of Public Water Supplies. NATO Science Series, vol 66. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4241-0_19
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DOI: https://doi.org/10.1007/978-94-011-4241-0_19
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