Abstract
Immunohistochemistry analysis was performed on deciduae and placentae from murine (several mating combinations) and human origin (caesarean term delivery or 8–10 weeks elective pregnancy termination) with anti IL-3, anti IL-4, or anti IL-10 polyclonals. In mice, the staining obtained for all three Th2 cytokines is esentially on placenta, with low staining of scattered labyrinthine areas and a much stronger staining of spongio trophoblast. In human, the pattern is more complex, but cytotrophoblast from early and late placentae are positive for all the three cytokines, Hoffbauër cells appear, with quantitative variations, potent producers of all three Th2 cytokines at term, but they are much less secreting in early gestation. Taken together, these data are in agreement with the concept of a strong Th2 cytokine shield at placental level in early gestation, with a slight decrease at term, whose regulation is discussed. Finally, we also show using 1 pr congenics that a prominent role for the Fas/Fas ligand system is not mandatory for ensuring the success of allogeneic pregnancy.
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Chaouat, G., Cayol, V., Mairovitz, V., Dubanchet, S. (1999). Localisation of the Th2 Cytokines IL-3, IL-4, IL-10 at the Murine Feto Maternal Interface During Pregnancy. In: Gupta, S.K. (eds) Reproductive Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4197-0_6
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DOI: https://doi.org/10.1007/978-94-011-4197-0_6
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