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Reproductive Immunology pp 358–365Cite as

Prospects of Developing Human Seminal Plasma Inhibin as a Male Immunocontraceptive

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Abstract

Immunization of adult male rats with a synthetic peptide corresponding to the region 1–17 of human seminal plasma inhibin (hSPI) resulted in agglutination of epididymal spermatozoa, severely affecting the fertility of the animals (75% reduction in fertility as compared to controls). This effect was found to be dependent on the antibody titre to hSPI. There was a significant rise in circulating FSH levels with LH and testosterone levels remaining unaffected. The histology of the testes and other reproductive organs also remained unaltered. These results suggest that the N-terminal 1–17 amino acid peptide of hSPI may hold promise as an immunogen for male immunocontraception.p

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Author information

Authors and Affiliations

  1. Institute for Research in Reproduction, Jehangir Merwanji Street, Mumbai, 400 012, India

    S. B. Moodbidri, G. R. Vanage, P. B. Mehta & K. S. N. Iyer

Authors
  1. S. B. Moodbidri
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  2. G. R. Vanage
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  3. P. B. Mehta
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  4. K. S. N. Iyer
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Editor information

Editors and Affiliations

  1. Gamete Antigen Laboratory, National Institute of Immunology, New Delhi, India

    Satish K. Gupta (Chief) (Chief)

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© 1999 Springer Science+Business Media Dordrecht

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Moodbidri, S.B., Vanage, G.R., Mehta, P.B., Iyer, K.S.N. (1999). Prospects of Developing Human Seminal Plasma Inhibin as a Male Immunocontraceptive. In: Gupta, S.K. (eds) Reproductive Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4197-0_37

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  • DOI: https://doi.org/10.1007/978-94-011-4197-0_37

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5825-4

  • Online ISBN: 978-94-011-4197-0

  • eBook Packages: Springer Book Archive

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