Abstract
Immunization of adult male rats with a synthetic peptide corresponding to the region 1–17 of human seminal plasma inhibin (hSPI) resulted in agglutination of epididymal spermatozoa, severely affecting the fertility of the animals (75% reduction in fertility as compared to controls). This effect was found to be dependent on the antibody titre to hSPI. There was a significant rise in circulating FSH levels with LH and testosterone levels remaining unaffected. The histology of the testes and other reproductive organs also remained unaltered. These results suggest that the N-terminal 1–17 amino acid peptide of hSPI may hold promise as an immunogen for male immunocontraception.p
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© 1999 Springer Science+Business Media Dordrecht
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Moodbidri, S.B., Vanage, G.R., Mehta, P.B., Iyer, K.S.N. (1999). Prospects of Developing Human Seminal Plasma Inhibin as a Male Immunocontraceptive. In: Gupta, S.K. (eds) Reproductive Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4197-0_37
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DOI: https://doi.org/10.1007/978-94-011-4197-0_37
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