Abstract
Several studies on animal models of pregnancy and a few on human pregnancy have led to the proposition that successful pregnancy is a T helper 2 (Th2) phenomenon, while vigorous Thl-type immunity, mediated by Thl-type cytokines, is deleterious to pregnancy. With the objective of examining Th1- and Th2-type bias in normal pregnancy and in pregnancy failure, we analysed the patterns of Th1- and Th2- type cytokine production in women with a history of successful pregnancy and in women with a history of unexplained recurrent spontaneous abortions (RSA). Peripheral blood mononuclear cells (PBMC) from 54 women with a history of normal pregnancy and 23 women with a history of unexplained RSA, obtained at delivery or on the day of abortion respectively, were activated with the mitogen phytohemagglutinin (PHA), after which the levels of four Th2 cytokines and three Th 1 cytokines were estimated. We found that the PBMC of women in the normal pregnancy group produced significantly higher levels of the Th2 cytokines interleukin (IL)-4, IL-5, IL-6 and IL-10 than did the PBMC of the RSA group. On the other hand, PBMC of the women with a history of RSA secreted higher levels of the Th1-type cytokines IL-2 and tumour necrosis factor (TNF) than the normal pregnancy group. These data support the notion that Th2-dominance is a feature of successful pregnancy and that unexplained recurrent spontaneous abortion is associated with an increase in Th-1 type reactivity.
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References
Chaouat G., Menu E., Mognetti B. Immunopathology of early pregnancy. Inf. Dis. Obstet Gynecol 1997; 5: 73–92.
Beaman K.D. Nidation, tolerance and immunotrophism. Am. J. Reprod. Immunol. 1990; 23: 54–56.
Raghupathy R., Krishnan L. Immunosuppressive mechanisms in normal pregnancy. Central Eur J. Immunol. 1996; 21: 133–140.
Arck P.C., Clark D.A. Immunobiology of the decidua. Curr. Top. Microbiol Immunol. 1997; 222: 45–66.
Mosmann T.R., Coffman R.L. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 1989; 7: 145–173.
Romagnani S. Lymphokine production by human T cells in disease states. Ann. Rev. Immunol. 1994; 12: 227–257.
Mosmann T.R., Sad S. The expanding universe of T-cell subsets. Immunol. Today 1996; 17: 138–146.
Garcia-Lloret M., Yui J., Winkler-Lowen B. and Guilbert L.J., J. Cell Physiol 1996; 167: 324–332.
Berkowitz R., Hill J.A., Kurtz C.B., Anderson D.J. Effects of products of activated leukocytes (lymphokines and monokines) on the growth of malignant trophoblast cells in vitro. Am. J. Obstet Gynecol. 1988; 151: 199–203.
Parant M. Possible mediators in endotoxin-induced abortions. Res. Immunol. 1990; 18: 478–482.
Chaouat G., Menu E., Clark D.A., Dy M., Minkowski M and Wegmann T.G. Control of fetal survival in CBA×DBA/2 mice by lymphokine therapy. J. Reprod. Fertil. 1990; 89: 447–458.
Tangri S., Wegmann T.G., Lin H. and Raghupathy R. Maternal anti-placental reactivity in natural immunologically-mediated spontaneous fetal resorptions. J. Immunol 1993; 152: 4903–4912.
Tangri S., Raghupathy R. Expression of cytokines in placentas of mice undergoing immunologically-mediated spontaneous fetal resorption. Biol. Reprod. 1993; 49: 850–857.
Gendron R.L., Baines M. Immunohistological analyses of decidual natural killer cells during spontaneous abortions in mice. Cell Immunol. 1988; 113: 261–267.
De Fougerolles R., Baines M. Modulation of natural killer activity influences resorption rates in CBA × DBA/2 matings. J. Reprod. Immunol. 1987; 11: 147–153.
Szekeres-Bartho J., Varga P. and Pacsa A.S. Immunologic factors contribute to the initiation of labor—Lymphocytic reactivity in term labour and threatened preterm delivery. Am. J. Obstet Gynecol. 1986; 155: 108–113.
Baines M.G., Duclos A.J., Antecka E., Haddad E.K. Decidual infiltration and activation of macrophages leads to early embryo loss. Am. J. Reprod. Immunol. 1997; 37: 471–477.
Maruyama T., Makino T., Sugi T., Matsubayashi H., Ozawa N., Nozawa S. Flow cytometric analyses of immune cell populations in human decidua from various types of first trimester pregnancy. Am. J. Obstet. Gynecol. 1993; 168: 1528–1536.
Clark D.A., Arck P.C., Mali R., Merali F.S., Manuel J., Chaouat G., Underwood J.L., Mowbray J.F. Psycho-neuro-cytokine/endocrine pathway in immunoregulation during pregnancy. Am. J. Reprod. Immunol. 1996; 35: 330–337.
Krishnan L., Guilbert L.J., Wegmann T.G., Belosevic M., Mosmann T.R. T helper 1 response against Leishmania major in pregnant C57BL6 mice increases implantation failure and fetal resorptions. J. Immunol. 1996; 156: 653–662.
Chaouat G., Meliani A.A., Martal J., Raghupathy R., Elliot J., Mosmann T., Wegmann TG. IL-10 prevents naturally occurring fetal loss in the CBA × DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vitro injection of IFN-t. J. Immunol. 1995; 154: 4261–4268.
Hill J.A., Polgar K., Anderson D.J.T helper 1-type cellular immunity to trophoblast in women with recurrent spontaneous abortions. J. Am. Med. Assoc. 1995; 273: 1933–1936.
Szekeres-Bartho J., Faust Z., Varga P., Szereday L., Kelemen K. The immunological potentiating effect of progesterone is manifested via controlling cytokine production. Am. J. Reprod. Immunol. 1996; 35: 348–351.
Marzi M., Vigano A., Trabattoni D., Villa M.L., Salvaggio A., Clerici E., Clerici M. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin. Exp. Immunol. 1996; 106: 127–133.
Wegmann T.G., Lin H., Guilbert L., Mosmann T.R. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14: 353–356.
Lin. H., Mosmann T.R., Guilbert L., Tuntipotat S., Wegmann T.G., Synthesis of Th2 cytokines at the maternal-fetal interface. J. Immunol. 1994; 151: 4562–4573.
Voisin G.-A., Raghupathy R. Immunodeviation of the immune response during pregnancy. In: Kurpisz M., Fernandez N. eds. Immunology of human reproduction. Oxford, U.K: BIOS Scientific Publishers, 1995: 335–353.
Holland D., Brestscher P., Russell A.S. Immunologic and inflammatory responses during pregnancy. Clin. Lab. Immunol. 1984; 14: 177–186.
Dresser D.W. The potentiating effect of pregnancy on humoral immune responses in mice. J. Reprod. Immunol 1991; 20: 253–266.
Luft B.J., Remington J.S. Effect of pregnancy on augmentation of natural killer cell activity by Corynebacterium parvum and Toxoplasma gondii. J. Immunol. 1984; 132: 2375–3288.
Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol. Today 18: 478–482.
Athanassakis I., Bleackley R.C., Paetkau Vet al., The immunostimulatory effect of T cells and T cell lymphokines on murine fetally-derived placental cells. J. Immunol. 1987; 138: 37–44.
Robertson S.A., Brannstrom M., Seamark R.F., Cytokines in rodent reproduction and the cytokine-endocrine interaction. Curr Opin Immunol. 1992; 4: 585–590.
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Raghupathy, R., Makhseed, M., Azizieh, F., Al-Azemi, M.M.K., Hassan, N.A., Bandar, A. (1999). Th1 and Th2 Cytokine Profiles in Successful Pregnancy and Unexplained Recurrent Abortions. In: Gupta, S.K. (eds) Reproductive Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4197-0_14
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DOI: https://doi.org/10.1007/978-94-011-4197-0_14
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