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Circadian Variation in Myocardial Ischemia and Infarction

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Advances in Noninvasive Electrocardiographic Monitoring Techniques

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 229))

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Abstract

Several cardiovascular phenomena including heart rate (1,2), blood pressure (3), premature ventricular contractions (4,5), sudden cardiac death (6), myocardial infarction (7), transient myocardial ischemia (1,2,5,8), and stroke are distributed unevenly according to the time of day. Understanding the pathophysiology of the morning preponderance of these vascular events will doubtless lead to development of successful strategies for prevention.

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References

  1. Mulcahy D, Keegan J, Cunningham D, et al. Circadian variation of total ischaemic burden and its alteration with antianginal agents. Lancet 1988; ii: 755–59.

    Google Scholar 

  2. Quyyumi AA, Mockus L, Wright C, Fox KM. Morphology of ambulatory ST-segment changes in patients with varying severity of coronary artery disease: investigation of the frequency of nocturnal ischaemia and coronary spasm. Br Heart J 1985; 53: 186–93.

    Article  PubMed  CAS  Google Scholar 

  3. Millar-Craig MW, Bishop CN, Raftery EB. Circadian variation of blood pressure. Lancet 1978; I: 795–97.

    Article  Google Scholar 

  4. Raeder EA, Hohnloser SH, Graboys TB, Podrid P, Lampert S, Lown B. Spontaneous variability and circadian distribution of ectopic activity in patients with malignant ventricular arrhythmia. J Am Coll Cardiol 1988; 12:656–61.

    Article  PubMed  CAS  Google Scholar 

  5. Lampert R, Rosenfeld L, Batsford W, Lee F, McPherson C. Circadian variation of sustained ventricular tachycardia in patients with coronary artery disease and implantable cardioverter defibrillators. Circulation 1994; 90: 241–47.

    Article  PubMed  CAS  Google Scholar 

  6. Muller JE, Ludmer PL, Willich SN, et al. Circadian variation in the frequency of sudden cardiac death. Circulation 1987; 75: 131–38.

    Article  PubMed  CAS  Google Scholar 

  7. Muller JE, Stone PH, Turi ZG, et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Eng J Med 1985; 313: 1315–22.

    Article  CAS  Google Scholar 

  8. Rocco MB, Barry J, Campbell S, et al. Circadian variation of transient myocardial ischemia in patients with coronary artery disease. Circulation 1987; 75: 395–400.

    Article  PubMed  CAS  Google Scholar 

  9. Mulcahy D, Dakak N, Zalos G, Andrews NP, Proschan M, Waclawiw MA, Schenke WH, Quyyumi AA. Patterns and underlying mechanisms of transient myocardial ischemia in stable coronary artery disease are the same in both sexes: a comparative study. J Am Coll Cardiol 1996;27: 1629–36.

    Article  PubMed  CAS  Google Scholar 

  10. Willich SN, Lowel H, Lewis M, Amtz R, Baur R, Winther K, Keil U, Schroder R, and TRIMM Study Group. Association of wake time and the onset of myocardial infarction. Circulation 1991;84[suppl VI]:VI-62–VI-67.

    Google Scholar 

  11. Hjalmarson A, Gilpin EA, Nicod P et al. Differing circadian patterns of symptom onset in subgroups of patients with acute myocardial infarction. Circulation 1989; 80:267–275.

    Article  PubMed  CAS  Google Scholar 

  12. Panza JA, Diodati JG, Callahan TS, Epstein SE, Quyyumi AA. Role of increases in heart rate in determining the occurrence and frequency of myocardial ischemia during daily life in patients with stable coronary artery disease. J Am Coll Cardiol 1992; 20: 1092–98.

    Article  PubMed  CAS  Google Scholar 

  13. Deedwania PC, Nelson JR. Pathophysiology of silent myocardial ischemia during daily life: hemodynamic evaluation by simultaneous electrocardiographic and blood pressure monitoring. Circulation 1990; 82: 1296–1304.

    Article  PubMed  CAS  Google Scholar 

  14. McLenachan JM, Weidinger FF, Barry J, et al. Relations between heart rate, ischemia, and drug therapy during daily life in patients with coronary artery disease. Circulation 1991; 83: 1263–70.

    Article  PubMed  CAS  Google Scholar 

  15. Quyyumi AA, Wright C, Mockus LJ, Fox KM. Mechanisms of nocturnal angina pectoris: importance of increased myocardial oxygen demand in patients with severe coronary artery disease. Lancet 1984; 2: 1207–9.

    Article  Google Scholar 

  16. Andrews TC, Fenton T, Toyosaki N, et al. Subsets of ambulatory myocardial ischemia based on heart rate activity: circadian distribution and response to anti-ischemic medications. Circulation 1993; 88: 92–100.

    Article  PubMed  CAS  Google Scholar 

  17. Parker JD, Testa MA, Jimenez AH, et al. Morning increase in ambulatory ischemia in patients with stable coronary artery disease. Importance of physical activity and increased cardiac demand. Circulation 1994; 89: 604–14.

    Article  PubMed  CAS  Google Scholar 

  18. Deanfïeld JE, Selwyn AP, Chierchia S, et al. Myocardial ischaemia during daily life in patients with stable angina: its relation to symptoms and heart rate changes. Lancet 1983; I: 753–58.

    Article  Google Scholar 

  19. Rozanski A, Bairey N, Krantz DS, et al. Mental stress and induction of silent myocardial ischemia in patients with coronary artery disease. N Eng J Med 1988; 318: 1005–12

    Article  CAS  Google Scholar 

  20. Turton MB, Deegan T. Circadian variations of plasma catecholamine, cortisol, and immunoreactive insulin concentrations in supine subjects. Clin Chim Acta 1974; 55: 389–97.

    Article  PubMed  CAS  Google Scholar 

  21. Gordon RD, Wolfe LK, Island DP, Liddle GW. A diurnal rhythm in plasma renin activity in man. J Clin Invest 1966; 45: 1587–92.

    Article  PubMed  CAS  Google Scholar 

  22. Quyyumi AA, Panza JA, Diodati JG, Lakatos E, Epstein SE. Circadian variation in ischemic threshold. A mechanism underlying the circadian variation in ischemic events. Circulation 1992; 86: 22–28.

    Article  PubMed  CAS  Google Scholar 

  23. Benhorin J, Banai S, Moriel M, et al. Circadian variation in ischemic threshold and their relation to the occurrence of ischemic episodes. Circulation 1993; 87: 808–14.

    Article  PubMed  CAS  Google Scholar 

  24. Yasue H, Omote S, Takizawaw A, Nagao M, Miwa K, Tanaka S. Circadian variation of exercise capacity in patients with Prinzmetals variant angina: role of exercise-induced coronary arterial spasm. Circulation 1979; 59: 938–48.

    Article  PubMed  CAS  Google Scholar 

  25. Berkenboom GM, Abramowicz M, Vandermoten P, Degre SG. Role of alpha-adrenergic coronary tone in exercise-induced angina pectoris. Am J Cardiol 1986; 57: 195–198.

    Article  PubMed  CAS  Google Scholar 

  26. Dakak N, Quyyumi AA, Eisenhoffer G, Goldstein DS, Cannon RO III Sympathetically-mediated effects of mental stress on cardiac microcirculation of patients with coronary artery disease. Am J Cardiol 1995;76:125–130

    Article  PubMed  CAS  Google Scholar 

  27. Collins P, Sheridan D. Improvement in angina pectoris withalpha adrenoceptor blockade. Br Heart J 1985; 53: 488–492.

    Article  PubMed  CAS  Google Scholar 

  28. Davies MJ, Thomas AC: Thrombosis and acute coronary artery lesions in sudden cardiac ischemic death. N Engl J Med 1984:310: 1137–1140.

    Article  PubMed  CAS  Google Scholar 

  29. Little WC, Constatinescu MS, Applegate RJ, et al. Can coronary angiography predict the site of subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 1988; 78: 1157–66.

    Article  PubMed  CAS  Google Scholar 

  30. Brezinski DA, Toiler GH, Müller JE, et al. Moming increase in platelet aggregability: Association with assumption of the upright posture. Circulation 1988; 78: 35–40.

    Article  PubMed  CAS  Google Scholar 

  31. Quyyumi AA, Circadian rhythms in cardiovascular disease. Am Heart J 1990; 120: 726–33.

    Article  PubMed  CAS  Google Scholar 

  32. Muller JE, Tofler GH, Stone PH. Circadian variation and trigger of onset of acute cardiovascular disease. Circulation 1989; 79:733–743.

    Article  PubMed  CAS  Google Scholar 

  33. Willich SN, Lewis M, Lowel H, Amiz HR, Schubert F, Schroder R. Physical exertion as a trigger of acute myocardial infarction. N Eng J Med 1993;328: 1686–1690.

    Article  Google Scholar 

  34. Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE. Triggering of acute myocardial infarction by heavy physical exertion. N Eng J of Med 1993 329:1677–83.

    Article  CAS  Google Scholar 

  35. Spencer FA, Goldberg RJ, Becker RC, Gore JM. Seasonal distribution of acute myocardial infarction in the second national registry of myocardial infarction. J Am Coll Cardiol 1998;31:1226–33.

    Article  PubMed  CAS  Google Scholar 

  36. Snyder SH, Bredt DS. Biological roles of nitric oxide. Sci Am 1992; 266: 68–71.

    PubMed  Google Scholar 

  37. Snyder SH, Bredt DS. Biological roles of nitric oxide. Sci Am 1992; 266: 74–7.

    Google Scholar 

  38. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Eng J Med 1993; 329: 2002–12.

    Article  CAS  Google Scholar 

  39. Dzau VJ. Vascular wall renin angiotensin pathway in control of the circulation. Am J Med 1984; 77:31–6.

    PubMed  CAS  Google Scholar 

  40. Vanhoutte PM, Shimokawa H. Endothelium-derived relaxing factor and coronary vasospasm. Circulation 1989; 80:1–9.

    Article  PubMed  CAS  Google Scholar 

  41. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990;81:494–7.

    Article  Google Scholar 

  42. Quyyumi AA, Dakak N, Andrews NP, Husain S, Arora S, Gilligan DM, Panza JA, Cannon RO m. Nitric oxide activity in the human coronary circulation: Impact of risk factors for coronary atherosclerosis. J Clin Invest 1995;95: 1747–1755.

    Article  PubMed  CAS  Google Scholar 

  43. Quyyumi AA, Mulcahy D, Andrews NP, Husain S, Panza JA, Cannon RO m. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia: comparison of acetylcholine and substance P. Circulation 1997;95:104–110.

    Article  PubMed  CAS  Google Scholar 

  44. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989; 83: 1774–1777.

    Article  PubMed  CAS  Google Scholar 

  45. Willich SN, Linderer T, Wegscheider K, Leizorowicz A, Alamercery I, Schroder R. Increased morning incidence of myocardial infarction in the ISAM study: absence with prior beta-adrenergic blockade. Circulation 1989; 80: 853–58.

    Article  PubMed  CAS  Google Scholar 

  46. Kidker PM, Manson JE, Buring JE, Muller JE, Hennekens CH. Circadian variation of acute myocardial infarction and the effect of low-dose aspirin in a randomized trial of physicianss. Circulation 1990;82:897–902.

    Article  Google Scholar 

  47. Yusuf S, Peto R, Lewis J et al. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985; 27: 335–371.

    Article  PubMed  CAS  Google Scholar 

  48. Quyyumi AA, Crake T, Wright CM, Mockus LJ, Fox KM. Medical treatment of patients with severe exertional and rest angina: double blind comparison of B blocker, calcium antagonist, and nitrate. Br Heart J 1987; 57: 505–11.

    Article  PubMed  CAS  Google Scholar 

  49. Parmley WW, Nesto RW, Singh BN, Deanfield J, Gottlieb SO, N-CAP Study Group. Attenuation of the circadian patterns o myocardial ischemia with nifedipine GITS in patients with chronic stable angina. J Am Coll Cardiol 1992;19:1380–9.

    Article  PubMed  CAS  Google Scholar 

  50. Stone PH, Gibson RS, Glasser SP, DeWood MA, Parker JD, Kawanishi DT, Crawford MH, Messineo FC, Shook TL, Raby K, Curtis DG, Hoop RS, Young PM, Braunwald E, ASIS Study Group. Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulation ischemia in patients with stable angina: differential effects on ambulatory ischemia, exercise performance, and anginal symptoms. Circulation 1990;82: 1962–1972.

    Article  PubMed  CAS  Google Scholar 

  51. Drexler H, Zeiher AM, Meinertz T, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 1991; 338: 1546–50.

    Article  PubMed  CAS  Google Scholar 

  52. Quyyumi AA, Dakak N, Diodati J, Gilligan DM, Panza JA, Cannon RO m. Effect of L-arginine on human coronary endothelium-dependent and physiologic vasodilation. J Am Coll Cardiol 1997;30: 1220–7

    Article  PubMed  CAS  Google Scholar 

  53. Mancini GBJ, Henry GC, Macaya C, O’Neill BJ, Pucillo AL, Carere RG, Wargovich TJ, Mudra H, L• scher TF, Kubaner MI, Haber HE, Uprichard ACG, Pepine CJ, Pitt B. Angiotensin-Converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease: the TREND (Trial on Reversing ENdothelial Dysfunction) Study. Circulation 1996;94:258–265.

    Article  PubMed  CAS  Google Scholar 

  54. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, Harrison DG: Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 1990;86:2109–2116.

    Article  PubMed  CAS  Google Scholar 

  55. Scandinavian Simvistatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvistatin Survival Study (4S). Lancet 1994; 344: 1383–89.

    Google Scholar 

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Authors
  1. Arshed A. Quyyumi
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Editors and Affiliations

  1. Department of Internal Medicine / Cardiology, University of Ulm, Ulm, Germany

    Hans-H. Osterhues  & Vinzenz Hombach  & 

  2. Medical Center, University of Rochester, Rochester, NY, USA

    Arthur J. Moss M.D. (Professor of Medicine) (Professor of Medicine)

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© 2000 Springer Science+Business Media Dordrecht

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Quyyumi, A.A. (2000). Circadian Variation in Myocardial Ischemia and Infarction. In: Osterhues, HH., Hombach, V., Moss, A.J. (eds) Advances in Noninvasive Electrocardiographic Monitoring Techniques. Developments in Cardiovascular Medicine, vol 229. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4090-4_24

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  • DOI: https://doi.org/10.1007/978-94-011-4090-4_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5796-7

  • Online ISBN: 978-94-011-4090-4

  • eBook Packages: Springer Book Archive

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