Abstract
Historically, biochemistry has been a descriptive science concerned with the identification and characterization of (sub-)cellular components. As more and more of these components became known, the focus of attention shifted from the components themselves to their interactions and interplay in the functioning of the living cell as a whole. However, such a description was typically limited to the effect of a certain property of a component on the whole system, e.g. the presence of allosteric feedback inhibition in an enzyme on the regulation of a whole metabolic pathway such as found in the biosynthesis of amino acids (Umbarger, 1978).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Agius, L. & Sherratt, H. S. A. (1977)Channelling in Intermediary MetabolismPortland Press,London
Höfer, T. & Heinrich, R. (1993) A second-order approach to metabolic control analysisJ. Theor. Biol. 16485–102
Hofmeyr, J.-H. S. (1997) Anaerobic energy metabolism in yeast as a supply—demand system, pp. 225–242 inNew Beer in an Old Bottle: Eduard Buchner and the Growth of Biochemical Knowledge(ed. Comish-Bowden, A.) Universitat de València, Valencia
Kholodenko, B. N. & Westerhoff, H. V. (1995) Control theory of group transfer pathwaysBiochem. Biophys. Acta 1229256–274
Ovádi, J. (1991) Physiological significance of metabolic channellingJ. Theor. Biol.152 1–22(with discussion by numerous authors in pp. 23–141)
Postma, P. W., Lengeler, J. W. & Jacobson, G. R. (1993) Phosphoenolpyruvate: carbohydrate phosphotransferase systems of bacteriaMicrobiol. Rev.57, 543–594
Reich, J. G. & Sel’kov, E. E. (1981)Energy Metabolism of the CellAcademic Press, London
Rohwer, J. M. (1997)Interaction of Functional Units in Metabolism: ControlandRegulation of the Bacterial Phosphoenolpyruvate-dependent Phosphotransferase SystemPh.D. thesis, University of Amsterdam
Rohwer, J. M., Postma, P. W., Kholodenko, B. N. & Westerhoff, H. V. (1998) Implications of macromolecular crowding for signal transduction and metabolite channelingProc. Natl. Acad. Sci. USA95, 10547–10552
Schuster, S. & Hilgetag, C. (1994) On elementary flux modes in biochemical reaction systems at steady stateJ. Biol. Syst. 2165–182
Small, J. R. & Kacser, H. (1993) Responses of metabolic systems to large changes in enzyme activities and effectors. I. the linear treatment of unbranched chainsEur. J. Biochem. 213613–624
Umbarger, H. E. (1978) Amino acid biosynthesis and its regulationAnnu. Rev. Biochem.47,533
Van Dam, K., Van der Vlag, J., Kholodenko, B. N. & Westerhoff, H. V. (1993) The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as highas two Eur. J. Biochem. 212791–799
Van der Vlag, J., Van’t Hof, R., Van Dam, K. & Postma, P. W. (1995) Control of glucose metabolism by the enzymes of the glucose phosphotransferase system inSalmonella typhimurium Eur. J. Biochem. 230 170–182
Whittaker, A. & Botha, F. C. (1997) Carbon partitioning during sucrose accumulation in sugarcane internodal tissuePlant Physiol.115, 1651–1659
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Rohwer, J.M., Hofmeyr, JH.S. (2000). An Integrated Approach to the Analysis of the Control and Regulation of Cellular Systems. In: Cornish-Bowden, A., Cárdenas, M.L. (eds) Technological and Medical Implications of Metabolic Control Analysis. NATO Science Series, vol 74. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4072-0_8
Download citation
DOI: https://doi.org/10.1007/978-94-011-4072-0_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-6189-3
Online ISBN: 978-94-011-4072-0
eBook Packages: Springer Book Archive