Abstract
The control of glycolytic flux is of great importance in physiology and biochemistry, medicine and biotechnology. It is also of great didactic importance: as the first metabolic pathway described in many biochemistry textbooks, and the first studied in detail by many biochemistry students, the control of glycolysis is one of the first specific areas in which concepts of metabolic control are taught. The usual description is of a dominant role for phosphofructokinase in glycolytic flux control. There is, however, considerable experimental evidence for the involvement of many steps in glycolytic flux control, some of which we have reviewed elsewhere along with theoretical considerations that support the role of multiple step activation in glycolytic flux control (Fell & Thomas, 1995; Thomas & Fell, 1996, 1998a; see also Chapter 30 in this book).
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© 2000 Springer Science+Business Media Dordrecht
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Thomas, S., Fell, D.A. (2000). Multisite Modulation in the Control of Glycolysis. In: Cornish-Bowden, A., Cárdenas, M.L. (eds) Technological and Medical Implications of Metabolic Control Analysis. NATO Science Series, vol 74. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4072-0_29
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DOI: https://doi.org/10.1007/978-94-011-4072-0_29
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