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β-adrenergic regulation of cardiac Na+ channel

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Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 182))

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Abstract

Calcium (Ca2+) channels in the heart are controlled by adrenergic neurotransmitters through adenosine 3′5′-cyclic monophosphate (cAMP)-mediated phosphorylation of the channel [1]. In biochemical studies, cardiac Na+ channels were also seen to undergo phosphorylation by cAMP, thereby suggesting the regulation of these channels by adrenergic neurotransmitters [2]. Although cardiac excitation and impulse transmission critically depends on the availability of voltage-gated Na+ channels, there is a paucity of information on effects of catecholamines or cAMP on the fast Na+ system [3,4] and available results are inconsistent.

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Authors
  1. Makoto Arita
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  2. Hikaru Muramatsu
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  3. Katsushige Ono
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  4. Tatsuto Kiyosue
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    Martin Morad

  2. National Institute for Physiological Sciences, Myodaiji, Okazaki 444, Japan

    Setsuro Ebashi

  3. Department of Physiology, II Physiological Institute, University of Saarland, D-66421, Homburg/Saar, Germany

    Wolfgang Trautwein

  4. Department of Pharmacology II, Faculty of Medicine, Osaka University, Yamada Oka 2-2, Suita, Osaka 565, Japan

    Yoshihisa Kurachi

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© 1996 Springer Science+Business Media Dordrecht

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Arita, M., Muramatsu, H., Ono, K., Kiyosue, T. (1996). β-adrenergic regulation of cardiac Na+ channel. In: Morad, M., Ebashi, S., Trautwein, W., Kurachi, Y. (eds) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Developments in Cardiovascular Medicine, vol 182. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3990-8_5

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  • DOI: https://doi.org/10.1007/978-94-011-3990-8_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5765-3

  • Online ISBN: 978-94-011-3990-8

  • eBook Packages: Springer Book Archive

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