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Signaling of calcium release in cardiac muscle

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Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 182))

Abstract

How voltage-gated DHP receptor controls the gating of the Ryanodine receptor in cardiac and skeletal muscle has been the central question of E-C coupling over the past two decades. Although the question remains still not fully answered, a number of biochemical, biophysical and molecular observations have furthered and focused the scientific understanding of the problem. In cardiac muscle, the general scheme that has emerged provides a primary role for transmembrane influx of Ca2+, not only in the direct activation of myofilament, but also in gating the release of intracellular Ca2+ stores [1–6].

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Authors
  1. Martin Morad
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    Martin Morad

  2. National Institute for Physiological Sciences, Myodaiji, Okazaki 444, Japan

    Setsuro Ebashi

  3. Department of Physiology, II Physiological Institute, University of Saarland, D-66421, Homburg/Saar, Germany

    Wolfgang Trautwein

  4. Department of Pharmacology II, Faculty of Medicine, Osaka University, Yamada Oka 2-2, Suita, Osaka 565, Japan

    Yoshihisa Kurachi

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© 1996 Springer Science+Business Media Dordrecht

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Morad, M. (1996). Signaling of calcium release in cardiac muscle. In: Morad, M., Ebashi, S., Trautwein, W., Kurachi, Y. (eds) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Developments in Cardiovascular Medicine, vol 182. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3990-8_32

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  • DOI: https://doi.org/10.1007/978-94-011-3990-8_32

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5765-3

  • Online ISBN: 978-94-011-3990-8

  • eBook Packages: Springer Book Archive

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