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Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters pp 343–349Cite as

Transient inward current and triggered activity

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 182))

Abstract

Afterdepolarizations represent a unique mechanism of abnormal impulse formations in which they are induced by initiating or triggering action potential. There are two types of afterdepolarizations, early and delayed afterdepolarizations. Early afterdepolarizations (EADs) occur during the course of preceding action potential repolarization, while delayed afterdepolarizations (DADs) develop after complete repolarization. DADs, which also have different terms such as transient depolarization, oscillatory afterpotential and so on, are damped membrane oscillations with amplitudes either less than reaching threshold or large enough to reach threshold. In the former case, DADs may appear as several membrane oscillations to subside gradually or may become large enough to propagate as subthreshold depolarization. In the latter case, they reach threshold to induce either a single spontaneous excitation, continuous rhythmic activity or runs of tachycardia.

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Authors
  1. Masayasu Hiraoka
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  2. Tohru Sawanobori
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  3. Seiko Kawano
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  4. Yuji Hirano
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    Martin Morad

  2. National Institute for Physiological Sciences, Myodaiji, Okazaki 444, Japan

    Setsuro Ebashi

  3. Department of Physiology, II Physiological Institute, University of Saarland, D-66421, Homburg/Saar, Germany

    Wolfgang Trautwein

  4. Department of Pharmacology II, Faculty of Medicine, Osaka University, Yamada Oka 2-2, Suita, Osaka 565, Japan

    Yoshihisa Kurachi

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© 1996 Springer Science+Business Media Dordrecht

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Hiraoka, M., Sawanobori, T., Kawano, S., Hirano, Y. (1996). Transient inward current and triggered activity. In: Morad, M., Ebashi, S., Trautwein, W., Kurachi, Y. (eds) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Developments in Cardiovascular Medicine, vol 182. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3990-8_29

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  • DOI: https://doi.org/10.1007/978-94-011-3990-8_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5765-3

  • Online ISBN: 978-94-011-3990-8

  • eBook Packages: Springer Book Archive

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