Abstract
To study the effects of lipophilic substances such as fatty acids on ion channel function, it is necessary to consider the biological structure and properties of the membrane lipid bilayer. In Singer and Nicholson’s fluid mosaic model of biological membranes, globular proteins are embedded to varying degrees into the fluid-like phospholipid bilayer, a basic structural unit of the membrane. The interaction of proteins with the lipid bilayer is via hydrophobic and electrostatic forces which determine the strength of attachment to the membrane. Therefore, lipid bilayers of biomembranes serve as a medium in which proteins work and interact with each other. Membrane lipids also serve important functions such as source and generation of intracellular second messengers, participation in biosynthetic pathways, and act as allos-teric effectors in the regulation of enzyme activity.
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Kim, D. (1996). Fatty acids and cardiac K+ channels. In: Morad, M., Ebashi, S., Trautwein, W., Kurachi, Y. (eds) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Developments in Cardiovascular Medicine, vol 182. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3990-8_26
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DOI: https://doi.org/10.1007/978-94-011-3990-8_26
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