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Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters pp 305–312Cite as

Pharmacological regulation of the cardiac ATP-sensitive K+ channel

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 182))

Abstract

ATP-sensitive K+ (KATP) channels represent a family of potassium channels inhibited by intracellular ATP (ATPi) [1–5]. These intracellular ligand-gated channels are believed to link cellular metabolism with membrane electrical activity. First described in cardiac myocytes, KATP channels have been identified in many tissues and associated with essential cellular functions such as hormone secretion, vasodilation, shortening of cardiac action potentials, ischemia-related preconditioning, regulation of skeletal muscle excitability, neurotransmitter release, appetite control, and oocyte maturation [1–5]. Our knowledge of the distribution and roles of KATP channels has been primarily based on the pharmacological manipulation of these channels [6,7].

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Authors
  1. Yoshihisa Kurachi
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  2. André Terzic
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  3. Ian Findlay
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    Martin Morad

  2. National Institute for Physiological Sciences, Myodaiji, Okazaki 444, Japan

    Setsuro Ebashi

  3. Department of Physiology, II Physiological Institute, University of Saarland, D-66421, Homburg/Saar, Germany

    Wolfgang Trautwein

  4. Department of Pharmacology II, Faculty of Medicine, Osaka University, Yamada Oka 2-2, Suita, Osaka 565, Japan

    Yoshihisa Kurachi

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© 1996 Springer Science+Business Media Dordrecht

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Kurachi, Y., Terzic, A., Findlay, I. (1996). Pharmacological regulation of the cardiac ATP-sensitive K+ channel. In: Morad, M., Ebashi, S., Trautwein, W., Kurachi, Y. (eds) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Developments in Cardiovascular Medicine, vol 182. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3990-8_25

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  • DOI: https://doi.org/10.1007/978-94-011-3990-8_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5765-3

  • Online ISBN: 978-94-011-3990-8

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