Abstract
Cardiac functions, namely automatic activity and contractility, can be modulated by hormones and neuromediators specifically released by nerves terminals. These compounds exert their actions on many steps of the excitation-contraction coupling which include ionic conductances, Ca homeostasis, intracellular pH, myofilament Ca-sensitivity as well as cellular metabolism. Over the past 25 years, extensive studies have been devoted to the analysis of α1- and β-adrenergic, or cholinergic regulation of the cardiac functions. This has led to tremendous advances in knowledge of the cellular effects of these neuromediators and of their underlying mechanisms of actions. Much little is known about the purinergic regulation of cardiac muscle activity. The diversity of purinergic receptors and agonists together with the multiplicity of the purinergic effects have made the analysis much more complicated.
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Vassort, G., Pucéat, M., Alvarez, J. (1996). Regulation of cardiac activity by ATP, a purine agonist. In: Morad, M., Ebashi, S., Trautwein, W., Kurachi, Y. (eds) Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Developments in Cardiovascular Medicine, vol 182. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3990-8_20
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DOI: https://doi.org/10.1007/978-94-011-3990-8_20
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