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Signal Transduction in Chemosensors of Modified Cyclodextrins

  • Chapter
Chemosensors of Ion and Molecule Recognition

Part of the book series: NATO ASI Series ((ASIC,volume 492))

Abstract

Signal transduction from guest binding to fluorescence response was performed with various chromophore-modified CDs (CD: cyclodextrin). Many dansyl-modified CDs were prepared as sensors for molecule detection. In the triad systems of fluorophore (dansyl), amino acid (D- or L-leucine), and CD, the chirality of the amino acid remarkably affects their molecular recognition and binding properties. Modified CDs bearing two naphthyl moieties give different responses to each guest, forming patterns that reflect the size and the shape of the guest compounds. Modified β-CDs with two pyrene moieties exhibit remarkable guest-responsive excimer emission. The effect of protein (avidin) as an environmental factor was examined in CD systems which have both fluorophore and protein binding sites. Several guest-responsive color-change indicators were also constructed on the same basis.

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Authors and Affiliations

  1. Department of Bioengineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226, Japan

    Akihiko Ueno, Hiroshi Ikeda & Juan Wang

Authors
  1. Akihiko Ueno
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  2. Hiroshi Ikeda
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  3. Juan Wang
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Editor information

Editors and Affiliations

  1. Laboratoire de Photochimie Organique, Université Bordeaux I, Talence, France

    J. P. Desvergne

  2. Irori Quantum Microchemistry, La Jolla, California, USA

    A. W. Czarnik

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Ueno, A., Ikeda, H., Wang, J. (1997). Signal Transduction in Chemosensors of Modified Cyclodextrins. In: Desvergne, J.P., Czarnik, A.W. (eds) Chemosensors of Ion and Molecule Recognition. NATO ASI Series, vol 492. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3973-1_8

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  • DOI: https://doi.org/10.1007/978-94-011-3973-1_8

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