Skip to main content

Topically applied copper preparations for anti-inflammatory therapy

  • Chapter

Abstract

While the recorded use of copper and its compounds for anti-inflammatory/ antiarthritic purposes goes back to the Egyptian papyri (2600 and 2200 BC), as well as Greek and Roman writings [1], it is only in relatively recent times that any serious attempt has been made to evaluate the potential therapeutic role of metallic copper in inflammatory diseases. The role of copper in inflammation continues to attract attention. This is reflected in the continued success of edited works such as this, drawing the various interdisciplinary approaches together in a coherent manner.

Keywords

  • Salicylic Acid
  • Copper Complex
  • Metallic Copper
  • Dermal Absorption
  • Serum Copper Level

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-94-011-3963-2_9
  • Chapter length: 8 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   129.00
Price excludes VAT (USA)
  • ISBN: 978-94-011-3963-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   169.99
Price excludes VAT (USA)
Hardcover Book
USD   249.00
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dollwet HHA, Sorenson JRJ. Historic uses of copper compound in medicine. Trace Elem Med 1985;2:80–87.

    Google Scholar 

  2. Jimenez-Hernandez RM, Frechilla D, Lasheras B et al. Inhibition of inflammation and gastric damage in rats by copper(II) complexes. Arzneimittelforschung. 1995;45(3):277–281.

    CAS  PubMed  Google Scholar 

  3. Whitehouse MW. Ambivalent role of copper in inflammatory disorders. Agents Actions. 1976;6:201–206.

    CrossRef  CAS  PubMed  Google Scholar 

  4. Berthon G. Is copper pro-or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation. Agents Actions. 1993;39:210–217.

    CrossRef  CAS  PubMed  Google Scholar 

  5. Weser U, Lengfelder E, Sellinger K, Schobotz L. Reactivity of chelated copper with superoxide. In: Sorenson JRJ, ed. Inflammatory Diseases and Copper. Clifton, New Jersey: Humana Press; 1982:513–529.

    CrossRef  Google Scholar 

  6. Sorenson JRJ. Copper-potentiation of non-steroidal antiinflammatory drugs. In: Berthon G, ed. Handbook of Metal-Ligand Interactions in Biological Fluids. New York: Dekker; 1995:1318–1324.

    Google Scholar 

  7. Frechilla D, Lasheras B, Ucelay M, Parrondo E, Craciunescu G, Cenarruzabeitia E. Antiinflammatory activity of some copper(II) complexes. Arzneimittelforschung. 1990;40:914–917.

    CAS  PubMed  Google Scholar 

  8. Auer DE, Ng JC, Seawright AA. Copper salicylate and copper phenylbutazone as topically applied anti-inflammatory agents in the rat and horse. J Vet Pharmacol Ther. 1990;13:67–75.

    CrossRef  CAS  PubMed  Google Scholar 

  9. Walker WR, Keats DM. An investigation of the therapeutic value of the copper ‘bracelet’; dermal assimilation of copper in arthritic/rheumatoid conditions. Agents Actions. 1976;6:454–459.

    CrossRef  CAS  PubMed  Google Scholar 

  10. Walker WR, Griffin BJ. The solubility of copper in human sweat. Search. 1976;7:100–101.

    CAS  Google Scholar 

  11. Odintsova NA. Permeability of human skin to potassium and copper ions and their ultrastructural localization. Deposited Doc. 1976;2969-76; 61–63.

    Google Scholar 

  12. Beveridge SJ, Walker WR. Formation of hydroxo-bridged copper (II) complexes by aeration of metallic copper. Aust J Chem. 1980;33:2331–2335.

    CrossRef  CAS  Google Scholar 

  13. Lewis AJ, Smith WE, Brown DH. Comparison of the anti-inflammatory activities of copper complexes in different models of inflammation. In: Sorenson JRJ, ed. Inflammatory Diseases and Copper. Clifton, NJ: Humana Press; 1982:303–338.

    CrossRef  Google Scholar 

  14. Walker WR, Beveridge SJ, Whitehouse MW. Anti-inflammatory activity of a dermally applied copper salicylate preparation (Alcusal). Agents Actions. 1980;10:38–47.

    CrossRef  CAS  PubMed  Google Scholar 

  15. Beveridge SJ. Copper therapy of inflammatory disorders: efficacy and biodistribution of topically applied copper complexes. In: Milanino R, Rainsford KD, Velo GP, eds. Copper and Zinc in Inflammation. Inflammation and Drug Therapy Series, vol. IV. Dordrecht: Kluwer; 1989:85–92.

    Google Scholar 

  16. Bertii JJ, Lipsky JJ. Transcutaneous drug delivery: a practical review. Mayo Clin Proc. 1995;70:581–586.

    CrossRef  Google Scholar 

  17. Steinstrasser I, Merkle HP. Drug metabolism of topically applied drugs: pathways and models. Pharm Acta Helv. 1995;70:3–24.

    CrossRef  CAS  PubMed  Google Scholar 

  18. Fairlie DP, Whitehouse MW. Transdermal delivery of inorganic complexes as metal drugs or nutritional supplements. Drug Des Deliv. 1991;8:83–102.

    CAS  Google Scholar 

  19. Singh P, Roberts MS. Dermal and underlying tissue pharmacokinetics of salicylic acid after topical application. J Pharmacokinet Biopharm. 1993;21:337–373.

    CAS  PubMed  Google Scholar 

  20. Singh P, Roberts MS. Skin permeability and local tissue concentrations of nonsteroidal antiinflammatory drugs after topical application. J Pharmacol Exp Ther. 1994;268:144–151.

    CAS  PubMed  Google Scholar 

  21. Beveridge SJ, Boettcher B, Walker WR, Whitehouse MW. Biodistribution of 64Cu in rats after topical applications of two lipophilic anti-inflammatory Cu(II) formulations. Agents Actions. 1984;14:291–295.

    CrossRef  CAS  PubMed  Google Scholar 

  22. A double-blind, cross-over, clinical trial of topically applied copper salicylate, Alcusal gel, with aged arthritics. Report by Drs GL James and SD Kennett, Adelaide, Australia, 1990. Report kindly provided by Professor B Boettcher, Department of Biological Sciences, The University of Newcastle.

    Google Scholar 

  23. A double blind clinical trial of Alcusal gel. Report by Drs Sando and James, Adelaide, Australia, 1990. Report kindly provided by Professor B Boettcher.

    Google Scholar 

  24. Beveridge SJ, Garrett IR, Whitehouse MW, Vernon-Roberts B, Brooks PM. Biodistribution of 64Cu in inflamed rats following administration of two anti-inflammatory copper complexes. Agents Actions. 1985;17:104–111.

    CrossRef  CAS  PubMed  Google Scholar 

  25. Sorenson JRJ. Copper complexes offer a physiological approach to treatment of chronic diseases. Prog Chem. 1989;26:437–568.

    CAS  Google Scholar 

  26. Betts WH, Garrett IR, Whitehouse MW. Therapy with metal complexes. In: Rainsford KD, ed. Anti-inflammatory and Anti-Rheumatic Drugs. Vol. 3. Boca Raton, FL: CRC Press; 1985:65–103.

    Google Scholar 

  27. Okuyama S, Hashimoto S, Aihara H, Willingham WM, Sorenson JRJ. Copper complexes of non-steroidal antiinflammatory agents: analgesic activity and possible opioid receptor activation. Agents Actions. 1987;21:355–359.

    CrossRef  Google Scholar 

  28. Auclair C, Gautero H, Boivin P. Effects of salicylate-copper complex on the metabolic activation in phagocytizing granulocytes. Biochem Pharmacol. 1980;29:3105–3109.

    CrossRef  CAS  PubMed  Google Scholar 

  29. Burkhard H, Schwingel M, Menninger M, Tschesche H. Oxygen radicals as effectors of cartilage destruction. Arthritis Rheum. 1986;29:379–387.

    CrossRef  Google Scholar 

  30. Brumas V, Brumas B, Berthon G. Copper (II) interactions with nonsteroidal anti-inflammatory agents. I. Salicylic and acetylsalicylic acid. J Inorg Biochem. 1995;57:191–207.

    CrossRef  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1998 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Beveridge, S.J. (1998). Topically applied copper preparations for anti-inflammatory therapy. In: Rainsford, K.D., Milanino, R., Sorenson, J.R.J., Velo, G.P. (eds) Copper and Zinc in Inflammatory and Degenerative Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3963-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-3963-2_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5757-8

  • Online ISBN: 978-94-011-3963-2

  • eBook Packages: Springer Book Archive