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Zinc in the regulation and therapy of inflammatory diseases and gastrointestinal ulceration

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Copper and Zinc in Inflammatory and Degenerative Diseases

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Abstract

Zinc is a key trace metal ion that is important in regulating a wide variety of metabolic, hormonal, immunological, neuronal and epithelial cell functions [1–4] (Chapters 2, 4 and 5). Over 300 enzymic reactions are known to depend on the presence of zinc [3]. These roles of zinc may be considered to have importance for (a) structural components of metalloproteins (e.g. in thymulin, gene-regulatory proteins, steroid receptors, (b) catalytic activity of enzymes (e.g. in various oxido-reductases, hydrolases, ligases, lyases) and (c) co-active functions (e.g. with Cu in superoxide dismutase, or phospholipase C [3].

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  1. Division of Biomedical Sciences, Sheffield Hallam University, Sheffield, S1 1WB, UK

    K. D. Rainsford & B. Zeitlin

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  1. K. D. Rainsford
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Editors and Affiliations

  1. Division of Biomedical Sciences, School of Science and Mathematics, Sheffield Hallam University, Pond Street, S1 1WB, Sheffield, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Policlinico di Borgo Roma, I-37134, Verona, Italy

    R. Milanino

  3. Department of Pharmacy, University of Arkansas for Medical Science Campus, 4301 W. Markham, Slot 522, 72205, Little Rock, AR, USA

    J. R. J. Sorenson

  4. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

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Rainsford, K.D., Zeitlin, B. (1998). Zinc in the regulation and therapy of inflammatory diseases and gastrointestinal ulceration. In: Rainsford, K.D., Milanino, R., Sorenson, J.R.J., Velo, G.P. (eds) Copper and Zinc in Inflammatory and Degenerative Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3963-2_6

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  • DOI: https://doi.org/10.1007/978-94-011-3963-2_6

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