Abstract
Following the discovery of Helicobacter pylori a second Helicobacter species was detected in human gastric mucosa which is now named H. heilmannii. In 1987 Dent et al were the first to describe this spiral organism in the gastric antrum1. McNulty in 1989 extended the report to six further cases and described the bacterium as Gram-negative, up to 7.5 μm long and approximately 0.9 μm wide, twice as large as H. pylori and with up to 12 flagella at each pole2. It closely resembled the spiral bacteria originally described and illustrated by Bizozzero (1893) in the stomach of dogs2. Based on morphology, site of colonization and host species the original name proposed was Gastrospirillum hominis3. Heilmann and Borchard (1991) described in a comprehensive way the histological pattern of the infected gastric mucosa and reported on 37 patients infected with Gastrospirillum hominis4. Subsequently Solnick et al. (1993), by analysis of the 16S ribosomal RNA, proved that Gastrospirillum hominis belongs to the genus Helicobacter5. Based on this finding the name H. heilmannii was proposed instead of Gastrospirillum hominis. Comparison of the 16S rRNA sequence of different H. heilmannii strains, however, shows that the sequences are highly homologous but not identical5,6. It was concluded that the individual strains, which all matched the criteria proposed by McNulty and colleagues, are likely to be several different Helicobacter species. Minor morphological differences in individual H. heilmannii strains were also observed by electron microscopy7. Currently the epithet ‘H. heilmanni’ is used as a working designation for unculturable gastric bacteria lacking an exact microbiological determination.
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References
Dent JC, McNulty CA, Uff JC, Wilkinson SP, Gear MW. Spiral organisms in the gastric antrum. Lancet. 1987;2:96.
Bizzozero G. Über die schlauchförmigen Drüsen des Magendarmkanals und die Beziehungen ihres Epithels zu dem Oberflächenepithel der Schleimhaut. Arch mikr Anat. 1893;42:82–152.
McNulty CA, Dent JC, Curry A, et al. New spiral bacterium in gastric mucosa. J Clin Pathol. 1989;42:585–591.
Heilmann KL, Borchard F. Gastritis due to spiral shaped bacteria other than Helicobacter pylori: clinical, histological, and ultrastructural findings. Gut. 1991;32:137–140.
Solnick JV, O’Rourke J, Lee A, Paster BJ, Dewhirst FE, Tompkins LS. An uncultured gastric spiral organism is a newly identified Helicobacter in humans. J Infect Dis. 1993;168:379–385.
Andersen LP, Boye K, Blom J, Hoick S, Norgaard A, Eisborg L. Characterization of a culturable ‘Gastrospirillum hominis’ (Helicobacter heilmannii) strain isolated from human gastric mucosa. J Clin Microbiol. 1999;37:1069–1076.
Wegmann W, Aschwanden M, Schaub N, Aenishanslin W, Gyr K. Gastritis associated with G astro spirillum hominis — a zoonosis? Schweiz Med Wochenschr. 1991;121:245–254.
Cantet F, Magras C, Marais A, Federighi M, Megraud F. Helicobacter species colonizing pig stomach: molecular characterization and determination of prevalence. Appl Environ Microbiol. 1999;65:4672–4676.
Hoick S, Ingeholm P, Blom J et al. The histopathology of human gastric mucosa inhabited by Helicobacter heilmannii-like (Gastrospirillum hominis) organisms, including the first culturable case. Apmis. 1997;105:746–756.
Andersen LP, Norgaard A, Hoick S, Blom J, Eisborg L. Isolation of a ‘Helicobacter heilmani’-like organism from the human stomach. Eur J Clin Microbiol Infect Dis. 1996;15:95–96.
Fox JG, Lee A. Gastric Campylobacter-like organisms: their role in gastric disease of laboratory animals. Lab Anim Sci. 1989;39:543–553.
Lee A, Chen M, Coltro N et al. Long-term infection of the gastric mucosa with Helicobacter species does induce atrophic gastritis in an animal model of Helicobacter pylori infection. Zentralbl Bakteriol. 1993;280:38–50.
Mendes EN, Queiroz DM, Rocha GA, Moura SB, Leite VH, Fonseca ME. Ultrastructure of a spiral micro-organism from pig gastric mucosa (‘Gastrospirillum suis’). J Med Microbiol. 1990;33:61–66.
De Groote D, van Doom LJ, Ducatelle R et al. ‘Candidatus Helicobacter suis’ a gastric Helicobacter from pigs, and its phylogenetic relatedness to other gastrospirilla. Int J Syst Bacteriol. 1999;49:1769–1777.
Mendes EN, Queiroz DM, Coimbra RS, Moura SB, Barbosa AJ, Rocha GA. Experimental infection of Wistar rats with ‘Gastrospirillum suis’ J Med Microbiol. 1996;44:105–109.
Flejou JF, Diomande I, Molas G et al. Human chronic gastritis associated with non-Helicobacter pylori spiral organisms (Gastrospirillum hominis). Four cases and review of the literature. Gastroenterol Clin Biol. 1990;14:806–810.
Stolte M, Kroher G, Meining A, Morgner A, Bayerdorffer E, Bethke B. A comparison of Helicobacter pylori and H. heilmannii gastritis. A matched control study involving 404 patients. Scand J Gastroenterol. 1997;32:28–33.
Borody TJ, George LL, Brandi S et al. Helicobacter pylori-negative duodenal ulcer. Am J Gastroenterol. 1991;86:1154–1157.
Goddard AF, Logan RP, Atherton JC, Jenkins D, Spiller RC. Healing of duodenal ulcer after eradication of Helicobacter heilmannii. Lancet. 1997;349:1815–1816.
Nakshabendi IM, Peebles SE, Lee FD, Russell RI. Spiral shaped microorganisms in the human duodenal mucosa. Postgrad Med J. 1991;67:846–847.
Yang H, Li X, Xu Z, Zhou D. ‘Helicobacter heilmanni’ infection in a patient with gastric cancer. Dig Dis Sci. 1995;40:1013–1014.
Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston, 1994. Am J Surg Pathol. 1996;20:1161–1181.
Regimbeau C, Karsenti D, Durand V et al. Low-grade gastric MALT lymphoma and Helicobacter heilmannii (Gastrospirillum hominis). Gastroenterol Clin Biol. 1998;22:720–723.
Morgner A, Lehn N, Anderson LP et al. Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma — complete remission after curing the infection. Gastroenterology. 2000 (In press).
Morgner A, Bayerdorffer E, Meining A, Stolte M, Kroher G. Helicobacter heilmannii and gastric cancer. Lancet. 1995;346:511–512.
Yang H, Goliger JA, Song M, Zhou D. High prevalence of Helicobacter heilmannii infection in China. Dig Dis Sci. 1998;43:1493.
Yali Z, Yamada N, Wen M, Matsuhisa T, Miki M. Gastrospirillum hominis and Helicobacter pylori infection in Thai individuals: comparison of histopathological changes of gastric mucosa. Pathol Int. 1998;48:507–511.
Jhala D, Jhala N, Lechago J, Haber M. Helicobacter heilmannii gastritis: association with acid peptic diseases and comparison with Helicobacter pylori gastritis. Mod Pathol. 1999;12:534–538.
Mazzucchelli L, Wilder-Smith CH, Ruchti C, Meyer-Wyss B, Merki HS. Gastrospirillum hominis in asymptomatic, healthy individuals. Dig Dis Sci. 1993;38:2087–2089.
Oliva MM, Lazenby AJ, Perman JA. Gastritis associated with Gastrospirillum hominis in children. Comparison with Helicobacter pylori and review of the literature. Mod Pathol. 1993;6:513–515.
Debongnie JC, Mairesse J, Donnay M, Dekoninck X. Touch cytology. A quick, simple, sensitive screening test in the diagnosis of infections of the gastrointestinal mucosa. Arch Pathol Lab Med. 1994;118:1115–1118.
Debongnie JC, Donnay M, Mairesse J. Gastrospirillum hominis (‘Helicobacter heilman’): a cause of gastritis, sometimes transient, better diagnosed by touch cytology? Am J Gastroenterol. 1995;90:411–416.
Mendes EN, Queiroz DM, Moura SB, Rocha GA. Mouse inoculation for the detection of non-cultivable gastric tightly spiralled bacteria. Braz J Med Biol Res. 1998;31:373–376.
Neiger R, Dieterich C, Burnens A et al. Detection and prevalence of Helicobacter infection in pet cats. J Clin Microbiol. 1998;36:634–637.
Fawcett PT, Gibney KM, Vinette KM. Helicobacter pylori can be induced to assume the morphology of Helicobacter heilmannii. J Clin Microbiol. 1999;37:1045–1048.
Queiroz DM, Cabrai MM, Nogueira AM, Barbosa AJ, Rocha GA, Mendes EN. Mixed gastric infection by Gastrospirillum hominis and Helicobacter pylori. Lancet. 1990;336:507–508.
Ierardi E, Monno R, Mongelli A et al. Gastrospirillum hominis associated chronic active gastritis: the first report from Italy. Ital J Gastroenterol. 1991;23:86–87.
Dieterich C, Wiesel P, Neiger R, Blum A, Corthesy-Theulaz I. Presence of multiple ‘Helicobacter heilmanni’ strains in an individual suffering from ulcers and in his two cats. J Clin Microbiol. 1998;36:1366–1370.
Thomson MA, Storey P, Greer R, Cleghorn GJ. Canine-human transmission of Gastrospirillum hominis. Lancet. 1994;343:1605–1607.
Lee A, Fox JG, Otto G, Dick EH, Krakowka S. Transmission of Helicobacter spp. A challenge to the dogma of faecal-oral spread. Epidemiol Infect. 1991;107:99–109.
Meining A, Kroher G, Stolte M. Animal reservoirs in the transmission of Helicobacter heilmannii. Results of a questionnaire-based study. Scand J Gastroenterol. 1998;33:795–798.
Norris CR, Marks SL, Eaton KA, Torabian SZ, Munn RJ, Solnick JV. Healthy cats are commonly colonized with ‘Helicobacter heilmanni’ that is associated with minimal gastritis. J Clin Microbiol. 1999;37:189–194.
Debongnie JC, Donnay M, Mairesse J, Lamy V, Dekoninck X, Ramdani B. Gastric ulcers and Helicobacter heilmannii. Eur J Gastroenterol Hepatol. 1998;10:251–254.
Wack RF, Eaton KA, Kramer LW. Treatment of gastritis in cheetahs (Acinonyx jubatus). J Zoo Wildl Med. 1997;28:260–266.
Yamamoto T, Matsumoto J, Shiota K et al. Helicobacter heilmannii associated erosive gastritis. Intern Med. 1999;38:240–243.
Tanaka M, Saitoh A, Narita T et al. Gastrospirillum hominus-associated gastritis: the first reported case in Japan. J Gastroenterol. 1994;29:199–202.
Lavelle JP, Landas S, Mitros FA, Conklin JL. Acute gastritis associated with spiral organisms from cats. Dig Dis Sci. 1994;39:744–750.
Fenjvesi A, Naumov B, Kovac I. Helicobacter heilmanni (Gastrospirillum hominis) as a new cause of gastritis-case report. Med Pregl. 1999;52:275–277.
Neiger R, Seiler G, Schmassmann A. Use of a urea breath test to evaluate short-term treatments for cats naturally infected with Helicobacter heilmannii. Am J Vet Res. 1999;60:880–883.
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Malfertheiner, P., Bohr, U.R.M., Günther, T. (2000). Infection with Helicobacter heilmannii (formerly Gastrospirillum horminis): characterization, epidemiology and therapy. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_9
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DOI: https://doi.org/10.1007/978-94-011-3927-4_9
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