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Mechanisms involved in the development of hypochlorhydria and pangastritis in Helicobacter pylori infection

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Helicobacter pylori

Abstract

Helicobacter pylori infection exerts diverse effects on gastric physiology. It may increase gastric acid secretion, reduce it or result in no overall change in acid output1. The disturbance in acid secretion is related to the pattern of gastritis induced by the infection (Figure 1). In subjects with an antral-predominant non-atrophic H. pylori gastritis, acid secretion is normal or increased. This is the pattern of gastritis seen in patients who develop duodenal ulceration. In other subjects it produces an atrophic pangastritis or body-predominant gastritis. This results in markedly reduced acid secretion or achlorhydria and is seen in patients who develop non-cardia gastric cancer.

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Authors
  1. K. E. L. Mccoll
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  2. E. El-Omar
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine Director) (Professor of Medicine Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 2000 Springer Science+Business Media Dordrecht

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Mccoll, K.E.L., El-Omar, E. (2000). Mechanisms involved in the development of hypochlorhydria and pangastritis in Helicobacter pylori infection. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_39

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_39

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5753-0

  • Online ISBN: 978-94-011-3927-4

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